Publications
2021
Klein J. Horn E. Ernst M. Leykauf T. Leupold T. Dorfner M. Wolf LS. Ignatova A. Kreis W. Munkert J. RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content Plant Cell Reports 2021 )ISSN: 0721-7714 10.1007/s00299-021-02707-3 Tropper M. Höhn S. Wolf LS. Fritsch J. , Kastner-Detter N. Rieck C. Munkert J. Meitinger N. Lanig H. , Kreis W. 21-Hydroxypregnane 21-O-malonylation, a crucial step in cardenolide biosynthesis, can be achieved by substrate-promiscuous BAHD-type phenolic glucoside malonyltransferases from Arabidopsis thaliana and homolog proteins from Digitalis lanata Phytochemistry 187 2021 ), Art.Nr.: 112710 ISSN: 0031-9422 10.1016/j.phytochem.2021.112710 Zanchett Schneider NF. , Menegaz D. , Andreotti Dagostin AL. , Persich L. , Rocha SC. , Pacheco Ramos AC. , Cortes VF. , Leite Fontes CF. , De Padua RM. , Munkert J. Kreis W. Braga FC. , Barbosa LA. , Mena Barreto Silva FR. , Oliveira Simoes CM. :Cytotoxicity of glucoevatromonoside alone and in combination with chemotherapy drugs and their effects on Na+,K+-ATPase and ion channels on lung cancer cells Molecular and Cellular Biochemistry 2021 )ISSN: 0300-8177 10.1007/s11010-020-04040-x
2020
Boff L. , Persich L. , Brambila P. , Ottoni FM. , Munkert J. Ramos GS. , Soares Viana AR. , Kreis W. Braga FC. , Alves RJ. , Maia de Pádua R. , Schneider NFZ. , Simões CMO. :Investigation of the cytotoxic activity of two novel digitoxigenin analogues on H460 lung cancer cells Anti-Cancer Drugs 31 2020 ), S. 452-462 ISSN: 0959-4973 10.1097/CAD.0000000000000872 Boff L. , Schneider NFZ. , Munkert J. Ottoni FM. , Ramos GS. , Kreis W. Braga FC. , Alves RJ. , Maia de Pádua R. , Simões CMO. :Elucidation of the mechanism of anti-herpes action of two novel semisynthetic cardenolide derivatives. Archives of Virology 2020 ), S. 1385-1396 ISSN: 0304-8608 10.1007/s00705-020-04562-1 Boff L. , Schreiber A. , Matos AdR. , Del Sarto JL. , Brunotte L. , Munkert J. Ottoni FM. , Ramos GS. , Kreis W. Braga FC. , Alves RJ. , Maia de Pádua R. , Simões CMO. , Ludwig S. :Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation Molecules 2020 )ISSN: 1420-3049 10.3390/molecules25204853 Horn E. Kemmler Y. , Kreis W. Munkert J. Cardenolide and glucosinolate accumulation in shoot cultures of Erysimum crepidifolium Rchb. In Vitro Cellular & Developmental Biology-Plant 2020 )ISSN: 1054-5476 10.1007/s11627-020-10135-3 Scheer R. , Alban S. , Becker H. , Beer AM. , Blaschek W. , Klein R. , Kreis W. Leneweit G. , Matthes H. , Spahn G. , Stange R. (Hrsg.):Die Mistel in der Tumortherapie 5, aktueller Stand der Forschung und klinische Anwendung Essen 2020 ISBN: 978-3-96562-030-8
2019
Boff L. , Munkert J. Ottoni FM. , Schneider NFZ. , Ramos GS. , Kreis W. Andrade SF. , De Souza Filho JD. , Braga FC. , Alves RJ. , De Padua RM. , Simões CMO. :Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives European Journal of Medicinal Chemistry 167 2019 ), S. 546-561 ISSN: 0223-5234 10.1016/j.ejmech.2019.01.076 Boff L. , Munkert J. Ottoni FM. , Zanchett Schneider NF. , Ramos GS. , Kreis W. De Andrade SF. , Dias De Souza Filho J. , Castro Braga F. , Alves RJ. , Maia De Padua R. , Simões CMO. :Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399709 Kreis W. Exploiting plant cell culture for natural product formation Journal of Applied Botany and Food Quality-Angewandte Botanik 92 2019 ), S. 216-225 ISSN: 1613-9216 10.5073/JABFQ.2019.092.030 Kreis W. Munkert J. Exploiting enzyme promiscuity to shape plant specialized metabolism Journal of Experimental Botany 70 2019 ), S. 1435-1445 ISSN: 0022-0957 10.1093/jxb/erz025 Leykauf T. Klein J. Ernst M. Kreis W. Munkert J. RNAi mediated knock down of 3 beta-hydroxysteroid dehydrogenases in Digitalis lanata shoot cultures 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399800 Rieck C. Geiger D. Munkert J. Messerschmidt K. , Petersen J. Strasser J. Meitinger N. Kreis W. Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae MicrobiologyOpen 2019 ), Art.Nr.: e925 ISSN: 2045-8827 10.1002/mbo3.925 Tropper M. Höhn S. Munkert J. Kreis W. BAHD-like malonyltransferase genes from Digitalis lanata and Arabidopsis thaliana and their putative role in cardenolide biosynthesis 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399788
2018
Meitinger N. Kreis W. Development and validation of a quick assay for the total glucosinolate content in horseradish (Armoracia rusticana) using glucose strips and a blood glucose meter Journal of Applied Botany and Food Quality-Angewandte Botanik 91 2018 ), S. 232-236 ISSN: 1613-9216 10.5073/JABFQ.2018.091.031 Schmidt K. Petersen J. Munkert J. Egerer-Sieber C. , Hornig M. , Muller Y. Kreis W. PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism. Phytochemistry 156 2018 ), S. 9-19 ISSN: 0031-9422 10.1016/j.phytochem.2018.08.012 Schneider NFZ. , Cerella C. , Lee JY. , Mazumder A. , Kim KR. , de Carvalho A. , Munkert J. De Padua RM. , Kreis W. Kim KW. , Christov C. , Dicato M. , Kim HJ. , Han BW. , Braga FC. , Simões CMO. , Diederich M. :Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-specific Cell Death Frontiers in Pharmacology 9 2018 ), Art.Nr.: 70 ISSN: 1663-9812 10.3389/fphar.2018.00070 Silva IT. , Munkert J. Nolte E. Schneider NFZ. , Rocha SC. , Ramos ACP. , Kreis W. Braga FC. , De Padua RM. , Taranto AG. , Cortes VF. , Barbosa LA. , Wach S. , Taubert H. Simões CMO. :Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+ -ATPase inhibition. Biomedicine & Pharmacotherapy 107 2018 ), S. 464-474 ISSN: 0753-3322 10.1016/j.biopha.2018.08.028 Yücesan B. , Eker İ. , Lazzarini LES. , Aslam N. , Mohammed A. , Pinto JEBP. , Kreis W. Gürel E. :Shoot-tip Cultivation and Cardenolide Content Analysis of Natural Populations of Digitalis lanata Ehrh. subsp. lanata (wooly foxglove) in Thrace Region International Journal of Agriculture and Wildlife Science 4 2018 ), S. 55-62 ISSN: 2149-8245 10.24180/ijaws.390582
2017
Kreis W. The Foxgloves (Digitalis) Revisited Planta Medica 2017 )ISSN: 0032-0943 10.1055/s-0043-111240 Kreis W. Munkert J. De Padua RM. :Biossíntese de metabólitos primários e secundários In: Letícia Bispo de Lima (Hrsg.): Farmacognosia do Produto Natural ao Medicamento Porto Alegre, Brazil Artmed Editora Ltda. 2017 , S. 147 - 166 ISBN: 978-85-8271-359-4 Munkert J. Kreis W. Herzglykoside und ihr Potenzial für die Tumortherapie Deutsche Zeitschrift für Onkologie 49 2017 ), S. 129-135 ISSN: 0931-0037 10.1055/s-0043-115681 Munkert J. Santiago Franco M. , Nolte E. Silva IT. , Oliveira Castilho R. , Ottoni FM. , Schneider NFZ. , Oliveira MC. , Taubert H. Bauer W. Andrade SF. , Alves RJ. , Simões CMO. , Braga FC. , Kreis W. De Padua RM. :Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture. Planta medica 2017 )ISSN: 1439-0221 10.1055/s-0043-109557 Nolte E. Wach S. , Silva IT. , Lukat S. Ekici AB. Munkert J. Müller-Uri F. Kreis W. Simões CMO. , Vera González J. Wullich B. Taubert H. Lai X. A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines Oncotarget 8 2017 ), S. 11676-11691 ISSN: 1949-2553 10.18632/oncotarget.14644 Schneider NFZ. , Persich L. , Rocha SC. , Ramos ACP. , Cortes VF. , Silva IT. , Munkert J. De Padua RM. , Kreis W. Taranto AG. , Barbosa LA. , Braga FC. , Simões CMO. :Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase Biomedicine & Pharmacotherapy 97 2017 ), S. 684-696 ISSN: 0753-3322 10.1016/j.biopha.2017.10.128 Schneider NFZ. , Silva IT. , Persich L. , de Carvalho A. , Rocha SC. , Marostica LL. , Ramos ACP. , Taranto AG. , De Padua RM. , Kreis W. Barbosa LA. , Braga FC. , Simões CMO. :Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation Molecular and Cellular Biochemistry 428 2017 ), S. 23-39 ISSN: 0300-8177 10.1007/s11010-016-2914-8
2016
Dingermann T. , Kreis W. Nieber K. , Rimpler H. , Zündorf I. :Reinhard Pharmazeutische Biologie, Grundlagen und Humanbiologie Stuttgart Wissenschaftliche Verlagsgesellschaft 2016 ISBN: 978-3-8047-3261-2 Eker İ. , Yücesan B. , Sameeullah M. , Welß W. Müller-Uri F. Gürel E. , Kreis W. Phylogeny of Anatolian (Turkey) species in the Digitalis sect. Globiflorae (Plantaginaceae) Phytotaxa 244 2016 ), S. 263-282 ISSN: 1179-3155 10.11646/phytotaxa.244.3.3 Kreis W. Lektine: Potentielle Quellen und Anwendungen In: Scheer Rainer, Alban Susanne, Becker Hans, Beer André-Michael, Blaschek Wolfgang, Kreis Wolfgang, Matthes Harald, Schilcher Heinz, Spahn Günther, Stange Rainer (Hrsg.): Die Mistel in der Tumortherapie 4. Aktueller Stand der Forschung und klinische Anwendung Essen KVC Verlag 2016 ISBN: 978-3-945150-68-9 Maia de Pádua R. , Meitinger N. Hennemann M. Schebitz P. , Waibel R. Löber S. Gmeiner P. Clark T. Kreis W. Spontaneous butenolide ring formation of pregnane-21-O-malonyl hemiesters under mild reaction conditions is facilitated by the 14β-hydroxy group present in all natural cardenolides Tetrahedron 72 2016 ), S. 4556-4563 ISSN: 0040-4020 10.1016/j.tet.2016.06.024 Meitinger N. Munkert J. Maia de Pádua R. , De Souza Filho JD. , Maid H. Bauer W. Braga FC. , Kreis W. The catalytic mechanism of the 3-ketosteroid isomerase of Digitalis lanata involves an intramolecular proton transfer and the activity is not associated with the 3 beta-hydroxysteroid dehydrogenase activity Tetrahedron Letters 57 2016 ), S. 1567-1571 ISSN: 0040-4039 10.1016/j.tetlet.2016.02.099 Rudolph K. Parthier C. , Egerer-Sieber C. , Geiger D. Muller Y. Kreis W. Müller-Uri F. Expression, crystallization and structure elucidation of γ-terpinene synthase from Thymus vulgaris Acta Crystallographica Section F: Structural Biology and Crystallization Communications 72 2016 ), S. 16-23 ISSN: 1744-3091 10.1107/S2053230X15023043 Sahin S. Eulenburg V. Kreis W. Villmann C. , Pischetsrieder M. Three-step test system for the identification of novel GABAa receptor modulating food plants Plant Foods For Human Nutrition 71 2016 ), S. 355-360 ISSN: 0921-9668 10.1007/s11130-016-0566-1 http://rdcu.be/nkD9 Yücesan B. , Mohammed A. , Eker İ. , Sameeullah M. , Demir-Ordu Ö. , Cihangir C. , Şahbaz N. , Kaya Ö. , Müller-Uri F. Kreis W. Gürel E. :In vitro propagation and cardenolide profiling of Digitalis ferruginea subsp schischkinii, a medicinally important foxglove species with limited distribution in Northern Turkey In Vitro Cellular & Developmental Biology-Plant 52 2016 ), S. 322-329 ISSN: 1054-5476 10.1007/s11627-016-9759-4 Yücesan B. , Mohammed A. , Eker İ. , Sameeullah M. , Demir-Ordu Ö. , Cihangir C. , Şahbaz N. , Kaya Ö. , Müller-Uri F. Kreis W. Gürel E. :In vitro propagation and cardenolide profiling of Digitalis ferruginea subsp. schischkinii, a medicinally important foxglove species with limited distribution in Northern Turkey In Vitro Cellular & Developmental Biology-Plant 2016 )ISSN: 1054-5476
2015
Mohammed A. , Yücesan B. , Demir-Ordu Ö. , Cihangir C. , Eker İ. , Kreis W. Gürel E. :In vitro regeneration and cardenolide determination of an endemic foxglove, Digitalis cariensis (Aegean Foxglove) In Vitro Cellular & Developmental Biology-Plant 51 2015 ), S. 438-444 ISSN: 1054-5476 10.1007/s11627-015-9697-6 Munkert J. Costa C. Budeanu O. , Petersen J. Bertolucci S. , Fischer G. Müller-Uri F. Kreis W. Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers Plant Biology 17 2015 ), S. 1113-1122 ISSN: 1435-8603 10.1111/plb.12361 Munkert J. Pollier J. , Miettinen K. , Van Moerkercke A. , Payne R. , Müller-Uri F. Burlat V. , O'Connor SE. , Memelink J. , Kreis W. Goossens A. :Iridoid Synthase Activity is Common among the Plant Progesterone 5β-Reductase Family Molecular Plant 8 2015 ), S. 136-152 ISSN: 1674-2052 10.1016/j.molp.2014.11.005 Nolte E. Sobel A. , Wach S. , Hertlein H. , Ebert N. Müller-Uri F. Slany R. Taubert H. Wullich B. Kreis W. The new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) efficiently suppresses cell growth in human leukemia and urologic tumor cell lines Anticancer Research 35 2015 ), S. 5271-5276 ISSN: 0250-7005 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942815459&origin=inward Petersen J. Lanig H. , Munkert J. Bauer P. Müller-Uri F. Kreis W. Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations Journal of Biomolecular Structure & Dynamics 2015 ), S. 1-14 ISSN: 0739-1102 10.1080/07391102.2015.1088797 Schneider NFZ. , Geller FC. , Persich L. , Marostica LL. , Maia de Pádua R. , Kreis W. Braga FC. , Simões CMO. :Inhibition of cell proliferation, invasion and migration by the cardenolides digitoxigenin monodigitoxoside and convallatoxin in human lung cancer cell line Natural Product Research 2015 ), S. 1-5 ISSN: 1478-6419 10.1080/14786419.2015.1055265
2014
Kreis W. Haug B. , Yücesan B. :Somaclonal variation of cardenolide content in Heywood's foxglove, a source for the antiviral cardenolide glucoevatromonoside, regenerated from permanent shoot culture and callus In Vitro Cellular & Developmental Biology-Plant 51 2014 ), S. 35-41 ISSN: 1054-5476 10.1007/s11627-014-9642-0 Loebers A. Müller-Uri F. Kreis W. A young root-specific gene (ArMY2) from horseradish encoding a MYR II myrosinase with kinetic perference for the root-specific glucosinolate gluconasturtiin Phytochemistry 99 2014 ), S. 26-35 ISSN: 0031-9422 10.1016/j.phytochem.2013.11.008 Meitinger N. Geiger D. Augusto TW. , Maia de Pádua R. , Kreis W. Purification of Δ(5)-3-ketosteroid isomerase from Digitalis lanata Phytochemistry 109 2014 ), S. 6-13 ISSN: 0031-9422 10.1016/j.phytochem.2014.10.025 Munkert J. Ernst M. Müller-Uri F. Kreis W. Identification and stress-induced expression of three 3β-hydroxysteroid dehydrogenases from Erysimum crepidifolium Rchb. and their putative role in cardenolide biosynthesis Phytochemistry 100 2014 ), S. 26-33 ISSN: 0031-9422 10.1016/j.phytochem.2014.01.006 Rudolph K. Bauer P. Schmid B. Müller-Uri F. Kreis W. Truncation of N-terminal regions of Digitalis lanata progesterone 5β-reductase alters catalytic efficiency and substrate preference Biochimie 101 2014 ), S. 31-38 ISSN: 0300-9084 10.1016/j.biochi.2013.12.010
2013
Kreis W. Müller-Uri F. Cardenolide aglycone formation in Digitalis In: Bach Thomas J., Rohmer Michel (Hrsg.): Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches New York Springer Science + Business Media 2013 , S. 425-438 ISBN: 978-1-4614-4062-8 10.1007/978-1-4614-4063-5_29 Scheer R. , Alban S. , Becker H. , Blaschek W. , Kemper F. , Kreis W. Matthes H. , Schilcher H. , Stange R. (Hrsg.):Die Mistel in der Tumortherapie 3. Aktueller Stand der Forschung und klinische Anwendung Essen 2013 ISBN: 978-3-86864-032-8 Yücesan B. , Müller-Uri F. Kreis W. Gürel E. :Cardenolide estimation in callus-mediated regenerants of Digitalis lamarckii Ivanina (dwarf foxglove) In Vitro Cellular & Developmental Biology-Plant 50 2013 ), S. 137-142 ISSN: 1054-5476 10.1007/s11627-013-9549-1
2012
Bauer P. Rudolph K. Müller-Uri F. Kreis W. Vein Patterning 1-encoded progesterone 5beta-reductase: Activity-guided improvement of catalytic efficiency Phytochemistry 77 2012 ), S. 53-59 ISSN: 0031-9422 10.1016/j.phytochem.2012.01.022 Durchschein K. , Wallner S. , Macheroux P. , Schwab W. , Winkler T. , Kreis W. Faber K. :Nicotinamide-Dependent Ene Reductases as Alternative Biocatalysts for the Reduction of Activated Alkenes European Journal of Organic Chemistry 2012 2012 ), S. 4963-4968 ISSN: 1434-193X 10.1002/ejoc.201200776 Maia de Pádua R. , Meitinger N. de Souza Filho JD. , Waibel R. Gmeiner P. Braga FC. , Kreis W. Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W.1.4) Steroids 77 2012 ), S. 1373-1380 ISSN: 0039-128X 10.1016/j.steroids.2012.07.016
2011
Bauer P. Kreis W. Curcumin in der Krebstherapie Deutsche Zeitschrift für Onkologie 41 2011 ), S. 144-149 ISSN: 0931-0037 10.1055/s-0030-1257694 Bauer P. Müller-Uri F. Kreis W. Burda E. , Munkert J. Progesterone 5β-reductase of Erysimum crepidifolium: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant protein Phytochemistry 72 2011 ), S. 1710-1717 ISSN: 0031-9422 10.1016/j.phytochem.2011.06.007 Bertol JW. , Rigotto C. , Maia de Pádua R. , Kreis W. Barardi CRM. , Braga FC. , Simões CMO. :Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata. Antiviral Research 92 2011 ), S. 73-90 ISSN: 0166-3542 10.1016/j.antiviral.2011.06.015 Clemente ES. , Müller-Uri F. Nebauer SG. , Segura J. , Kreis W. Arrillaga I. :Digitalis In: Kole Chittaranjan (Hrsg.): Wild Crop Relatives: Genomic and Breeding Resources, Plantaton and Ornamental Crops Berlin Heidelberg Springer 2011 , S. 73-112 ISBN: 978-3-642-21201-7 10.1007/978-3-642-21200-0
2010
Bauer P. Munkert J. Brydziun M. , Burda E. , Müller-Uri F. Gröger H. , Muller Y. Kreis W. Highly conserved progesterone 5β-reductase (P5βR) genes, from 5β-cardenolide-free and 5β-cardenolide-producing angiosperms. Phytochemistry 71 2010 ), S. 1495-1505 ISSN: 0031-9422 10.1016/j.phytochem.2010.06.004 Baumgertel A. , Loebers A. Kreis W. Buckwheat is a Source for the Herbal Drug Fagopyri herba: Rutin Content and Activity of Flavonoid-Degrading Enzymes during Plant Development. The European Journal of Plant Science and Biotechnology Special Issue 1 2010 ), S. 82-86 ISSN: 1752-3842 Kreis W. Enzyme bei der Gewinnung von Drogen und der Herstellung von Phytopharmaka. In: Hänsel Rudolf, Sticher Otto (Hrsg.): Pharmakognosie - Phytopharmazie Berlin Heidelberg NY Springer 2010 , S. 273-279 ISBN: 978-3-642-00962-4 Kreis W. Prinzipien des Sekundärstoffwechsels In: Hänsel Rudolf, Sticher Otto (Hrsg.): Pharmakognosie - Phytopharmazie Belin, Heidelberg, New York Springer 2010 , S. 3-27 ISBN: 978-3-642-00962-4 Kreis W. Müller-Uri F. Biochemistry of sterols, cardiac glycosides, brassinosteroids, phytoecdysteroids and steroid saponins In: Wink M (Hrsg.): Biochemistry of Plant Secondary Metabolism. Annual Review Plant Sheffield CRC Press 2010 , S. 304-363 ISBN: 9781405183970 10.1002/9781444320503.ch6 Müller-Uri F. Kreis W. Recent Advances in Cardenolide Research. In: Journal of Academy of Sciences of Moldova (Hrsg.): Buletinul Academiei de Stiinte a Moldovei Chisinau 2010 , S. 45-52
2009
Burda E. , Kraußer M. Fischer G. Hummel W. , Müller-Uri F. Kreis W. Gröger H. :Recombinant Δ4,5-steroid 5β-reductases as biocatalysts for the reduction of activated C=C-double bonds in acyclic and monocyclic molecules dvanced Synthesis & Catalysis 351 2009 ), S. 2787-2790 ISSN: 0941-1216 10.1002/adsc.200900024 Coniglio M. , Kreis W. Immobilization of Flavonol 3-O-beta-Heterodisaccharidase on Porous Glass and Production of Rutinose from Rutin. Planta Medica 75 2009 ), S. 1459-1461 ISSN: 0032-0943 10.1055/s-0029-1185703 Dingermann T. , Kreis W. Rimpler H. , Zündorf I. :Reinhard Pharmazeutische Biologie 1, Grundlagen für Studium und Praxis Stuttgart Wissenschaftliche Verlagsgesellschaft mbH 2009 ISBN: 978-3-8047-2107-4 Herl V. , Fischer G. Reva VA. , Stiebritz M. , Muller Y. Müller-Uri F. Kreis W. The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Δ4,5-steroid 5β-reductase activity in Arabidopsis thaliana L. Biochimie 91 2009 ), S. 517-525 ISSN: 0300-9084 10.1016/j.biochi.2008.12.005 Kreis W. Fortschritte bei der Strukturaufklärung von Inhaltsstoffen der Mistel In: Scheer Rainer, Alban Susanne, Becker Hans, Holzgrabe Ulrike, Kemper Fritz, Kreis Wolfgang, Matthes Harald, Schilcher Heinz (Hrsg.): Die Mistel in der Tumortherapie 2. Aktueller Stand der Forschung und klinische Anwendung. Essen KVC-Verlag 2009 , S. 17-29 ISBN: 978-3-933351-82-1 Kreis W. Sekundäre Pflanzenstoffe und Krebs. Deutsche Zeitschrift für Onkologie 41 2009 ), S. 100-108 ISSN: 0931-0037 10.1055/s-0029-1213576 Schebitz P. , Nothdurft L. , Hensel A. , Müller-Uri F. Kreis W. Norcholanic acids as substrates for recombinant 3β-hydroxysteroid dehydrogenase and progesterone 5β-reductase, enzymes of the 5β-cardenolide biosynthesis Tetrahedron Letters 51 2009 ), S. 367-370 ISSN: 0040-4039 10.1016/j.tetlet.2009.11.029
2008
Kreis W. Christmann A. :Burren - Rocks and Loughs. Student und Praktikant 2008 ), S. 80-84 ISSN: 0721-8672 Kuate SP. , Maia de Pádua R. , Eisenbeiß WF. Kreis W. Purification and characterization of malonyl-coenzyme A: 21-hydroxypregnane 21-O-malonyltransferase (Dp21MaT) from leaves of Digitalis purpurea L. Phytochemistry 69 2008 ), S. 619-626 ISSN: 0031-9422 10.1016/j.phytochem.2007.08.025 Maia de Pádua R. , Waibel R. Kuate SP. , Schebitz P. , Hahn S. , Gmeiner P. Kreis W. A simple chemical method for synthesizing malonyl hemiesters of 21-hydroxy-pregnanes, potential intermediates in cardenolide biosynthesis. Steroids 73 2008 ), S. 458-465 ISSN: 0039-128X 10.1016/j.steroids.2007.12.012 Thorn A. , Egerer-Sieber C. , Jäger C. Herl V. , Müller-Uri F. Kreis W. Muller Y. The crystal structure of progesterone 5beta-reductase from Digitalis lanata defines a novel class of short-chain dehydrogenases/reductases Journal of Biological Chemistry 283 2008 ), S. 17260-17269 ISSN: 0021-9258 10.1074/jbc.M706185200
2021
Klein J. Horn E. Ernst M. Leykauf T. Leupold T. Dorfner M. Wolf LS. Ignatova A. Kreis W. Munkert J. RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content Plant Cell Reports 2021 )ISSN: 0721-7714 10.1007/s00299-021-02707-3 Tropper M. Höhn S. Wolf LS. Fritsch J. , Kastner-Detter N. Rieck C. Munkert J. Meitinger N. Lanig H. , Kreis W. 21-Hydroxypregnane 21-O-malonylation, a crucial step in cardenolide biosynthesis, can be achieved by substrate-promiscuous BAHD-type phenolic glucoside malonyltransferases from Arabidopsis thaliana and homolog proteins from Digitalis lanata Phytochemistry 187 2021 ), Art.Nr.: 112710 ISSN: 0031-9422 10.1016/j.phytochem.2021.112710 Zanchett Schneider NF. , Menegaz D. , Andreotti Dagostin AL. , Persich L. , Rocha SC. , Pacheco Ramos AC. , Cortes VF. , Leite Fontes CF. , De Padua RM. , Munkert J. Kreis W. Braga FC. , Barbosa LA. , Mena Barreto Silva FR. , Oliveira Simoes CM. :Cytotoxicity of glucoevatromonoside alone and in combination with chemotherapy drugs and their effects on Na+,K+-ATPase and ion channels on lung cancer cells Molecular and Cellular Biochemistry 2021 )ISSN: 0300-8177 10.1007/s11010-020-04040-x
2020
Boff L. , Persich L. , Brambila P. , Ottoni FM. , Munkert J. Ramos GS. , Soares Viana AR. , Kreis W. Braga FC. , Alves RJ. , Maia de Pádua R. , Schneider NFZ. , Simões CMO. :Investigation of the cytotoxic activity of two novel digitoxigenin analogues on H460 lung cancer cells Anti-Cancer Drugs 31 2020 ), S. 452-462 ISSN: 0959-4973 10.1097/CAD.0000000000000872 Boff L. , Schneider NFZ. , Munkert J. Ottoni FM. , Ramos GS. , Kreis W. Braga FC. , Alves RJ. , Maia de Pádua R. , Simões CMO. :Elucidation of the mechanism of anti-herpes action of two novel semisynthetic cardenolide derivatives. Archives of Virology 2020 ), S. 1385-1396 ISSN: 0304-8608 10.1007/s00705-020-04562-1 Boff L. , Schreiber A. , Matos AdR. , Del Sarto JL. , Brunotte L. , Munkert J. Ottoni FM. , Ramos GS. , Kreis W. Braga FC. , Alves RJ. , Maia de Pádua R. , Simões CMO. , Ludwig S. :Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation Molecules 2020 )ISSN: 1420-3049 10.3390/molecules25204853 Horn E. Kemmler Y. , Kreis W. Munkert J. Cardenolide and glucosinolate accumulation in shoot cultures of Erysimum crepidifolium Rchb. In Vitro Cellular & Developmental Biology-Plant 2020 )ISSN: 1054-5476 10.1007/s11627-020-10135-3 Scheer R. , Alban S. , Becker H. , Beer AM. , Blaschek W. , Klein R. , Kreis W. Leneweit G. , Matthes H. , Spahn G. , Stange R. (Hrsg.):Die Mistel in der Tumortherapie 5, aktueller Stand der Forschung und klinische Anwendung Essen 2020 ISBN: 978-3-96562-030-8
2019
Boff L. , Munkert J. Ottoni FM. , Schneider NFZ. , Ramos GS. , Kreis W. Andrade SF. , De Souza Filho JD. , Braga FC. , Alves RJ. , De Padua RM. , Simões CMO. :Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives European Journal of Medicinal Chemistry 167 2019 ), S. 546-561 ISSN: 0223-5234 10.1016/j.ejmech.2019.01.076 Boff L. , Munkert J. Ottoni FM. , Zanchett Schneider NF. , Ramos GS. , Kreis W. De Andrade SF. , Dias De Souza Filho J. , Castro Braga F. , Alves RJ. , Maia De Padua R. , Simões CMO. :Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399709 Kreis W. Exploiting plant cell culture for natural product formation Journal of Applied Botany and Food Quality-Angewandte Botanik 92 2019 ), S. 216-225 ISSN: 1613-9216 10.5073/JABFQ.2019.092.030 Kreis W. Munkert J. Exploiting enzyme promiscuity to shape plant specialized metabolism Journal of Experimental Botany 70 2019 ), S. 1435-1445 ISSN: 0022-0957 10.1093/jxb/erz025 Leykauf T. Klein J. Ernst M. Kreis W. Munkert J. RNAi mediated knock down of 3 beta-hydroxysteroid dehydrogenases in Digitalis lanata shoot cultures 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399800 Rieck C. Geiger D. Munkert J. Messerschmidt K. , Petersen J. Strasser J. Meitinger N. Kreis W. Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae MicrobiologyOpen 2019 ), Art.Nr.: e925 ISSN: 2045-8827 10.1002/mbo3.925 Tropper M. Höhn S. Munkert J. Kreis W. BAHD-like malonyltransferase genes from Digitalis lanata and Arabidopsis thaliana and their putative role in cardenolide biosynthesis 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399788
2018
Meitinger N. Kreis W. Development and validation of a quick assay for the total glucosinolate content in horseradish (Armoracia rusticana) using glucose strips and a blood glucose meter Journal of Applied Botany and Food Quality-Angewandte Botanik 91 2018 ), S. 232-236 ISSN: 1613-9216 10.5073/JABFQ.2018.091.031 Schmidt K. Petersen J. Munkert J. Egerer-Sieber C. , Hornig M. , Muller Y. Kreis W. PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism. Phytochemistry 156 2018 ), S. 9-19 ISSN: 0031-9422 10.1016/j.phytochem.2018.08.012 Schneider NFZ. , Cerella C. , Lee JY. , Mazumder A. , Kim KR. , de Carvalho A. , Munkert J. De Padua RM. , Kreis W. Kim KW. , Christov C. , Dicato M. , Kim HJ. , Han BW. , Braga FC. , Simões CMO. , Diederich M. :Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-specific Cell Death Frontiers in Pharmacology 9 2018 ), Art.Nr.: 70 ISSN: 1663-9812 10.3389/fphar.2018.00070 Silva IT. , Munkert J. Nolte E. Schneider NFZ. , Rocha SC. , Ramos ACP. , Kreis W. Braga FC. , De Padua RM. , Taranto AG. , Cortes VF. , Barbosa LA. , Wach S. , Taubert H. Simões CMO. :Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+ -ATPase inhibition. Biomedicine & Pharmacotherapy 107 2018 ), S. 464-474 ISSN: 0753-3322 10.1016/j.biopha.2018.08.028 Yücesan B. , Eker İ. , Lazzarini LES. , Aslam N. , Mohammed A. , Pinto JEBP. , Kreis W. Gürel E. :Shoot-tip Cultivation and Cardenolide Content Analysis of Natural Populations of Digitalis lanata Ehrh. subsp. lanata (wooly foxglove) in Thrace Region International Journal of Agriculture and Wildlife Science 4 2018 ), S. 55-62 ISSN: 2149-8245 10.24180/ijaws.390582
2017
Kreis W. The Foxgloves (Digitalis) Revisited Planta Medica 2017 )ISSN: 0032-0943 10.1055/s-0043-111240 Kreis W. Munkert J. De Padua RM. :Biossíntese de metabólitos primários e secundários In: Letícia Bispo de Lima (Hrsg.): Farmacognosia do Produto Natural ao Medicamento Porto Alegre, Brazil Artmed Editora Ltda. 2017 , S. 147 - 166 ISBN: 978-85-8271-359-4 Munkert J. Kreis W. Herzglykoside und ihr Potenzial für die Tumortherapie Deutsche Zeitschrift für Onkologie 49 2017 ), S. 129-135 ISSN: 0931-0037 10.1055/s-0043-115681 Munkert J. Santiago Franco M. , Nolte E. Silva IT. , Oliveira Castilho R. , Ottoni FM. , Schneider NFZ. , Oliveira MC. , Taubert H. Bauer W. Andrade SF. , Alves RJ. , Simões CMO. , Braga FC. , Kreis W. De Padua RM. :Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture. Planta medica 2017 )ISSN: 1439-0221 10.1055/s-0043-109557 Nolte E. Wach S. , Silva IT. , Lukat S. Ekici AB. Munkert J. Müller-Uri F. Kreis W. Simões CMO. , Vera González J. Wullich B. Taubert H. Lai X. A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines Oncotarget 8 2017 ), S. 11676-11691 ISSN: 1949-2553 10.18632/oncotarget.14644 Schneider NFZ. , Persich L. , Rocha SC. , Ramos ACP. , Cortes VF. , Silva IT. , Munkert J. De Padua RM. , Kreis W. Taranto AG. , Barbosa LA. , Braga FC. , Simões CMO. :Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase Biomedicine & Pharmacotherapy 97 2017 ), S. 684-696 ISSN: 0753-3322 10.1016/j.biopha.2017.10.128 Schneider NFZ. , Silva IT. , Persich L. , de Carvalho A. , Rocha SC. , Marostica LL. , Ramos ACP. , Taranto AG. , De Padua RM. , Kreis W. Barbosa LA. , Braga FC. , Simões CMO. :Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation Molecular and Cellular Biochemistry 428 2017 ), S. 23-39 ISSN: 0300-8177 10.1007/s11010-016-2914-8
2016
Dingermann T. , Kreis W. Nieber K. , Rimpler H. , Zündorf I. :Reinhard Pharmazeutische Biologie, Grundlagen und Humanbiologie Stuttgart Wissenschaftliche Verlagsgesellschaft 2016 ISBN: 978-3-8047-3261-2 Eker İ. , Yücesan B. , Sameeullah M. , Welß W. Müller-Uri F. Gürel E. , Kreis W. Phylogeny of Anatolian (Turkey) species in the Digitalis sect. Globiflorae (Plantaginaceae) Phytotaxa 244 2016 ), S. 263-282 ISSN: 1179-3155 10.11646/phytotaxa.244.3.3 Kreis W. Lektine: Potentielle Quellen und Anwendungen In: Scheer Rainer, Alban Susanne, Becker Hans, Beer André-Michael, Blaschek Wolfgang, Kreis Wolfgang, Matthes Harald, Schilcher Heinz, Spahn Günther, Stange Rainer (Hrsg.): Die Mistel in der Tumortherapie 4. Aktueller Stand der Forschung und klinische Anwendung Essen KVC Verlag 2016 ISBN: 978-3-945150-68-9 Maia de Pádua R. , Meitinger N. Hennemann M. Schebitz P. , Waibel R. Löber S. Gmeiner P. Clark T. Kreis W. Spontaneous butenolide ring formation of pregnane-21-O-malonyl hemiesters under mild reaction conditions is facilitated by the 14β-hydroxy group present in all natural cardenolides Tetrahedron 72 2016 ), S. 4556-4563 ISSN: 0040-4020 10.1016/j.tet.2016.06.024 Meitinger N. Munkert J. Maia de Pádua R. , De Souza Filho JD. , Maid H. Bauer W. Braga FC. , Kreis W. The catalytic mechanism of the 3-ketosteroid isomerase of Digitalis lanata involves an intramolecular proton transfer and the activity is not associated with the 3 beta-hydroxysteroid dehydrogenase activity Tetrahedron Letters 57 2016 ), S. 1567-1571 ISSN: 0040-4039 10.1016/j.tetlet.2016.02.099 Rudolph K. Parthier C. , Egerer-Sieber C. , Geiger D. Muller Y. Kreis W. Müller-Uri F. Expression, crystallization and structure elucidation of γ-terpinene synthase from Thymus vulgaris Acta Crystallographica Section F: Structural Biology and Crystallization Communications 72 2016 ), S. 16-23 ISSN: 1744-3091 10.1107/S2053230X15023043 Sahin S. Eulenburg V. Kreis W. Villmann C. , Pischetsrieder M. Three-step test system for the identification of novel GABAa receptor modulating food plants Plant Foods For Human Nutrition 71 2016 ), S. 355-360 ISSN: 0921-9668 10.1007/s11130-016-0566-1 http://rdcu.be/nkD9 Yücesan B. , Mohammed A. , Eker İ. , Sameeullah M. , Demir-Ordu Ö. , Cihangir C. , Şahbaz N. , Kaya Ö. , Müller-Uri F. Kreis W. Gürel E. :In vitro propagation and cardenolide profiling of Digitalis ferruginea subsp schischkinii, a medicinally important foxglove species with limited distribution in Northern Turkey In Vitro Cellular & Developmental Biology-Plant 52 2016 ), S. 322-329 ISSN: 1054-5476 10.1007/s11627-016-9759-4 Yücesan B. , Mohammed A. , Eker İ. , Sameeullah M. , Demir-Ordu Ö. , Cihangir C. , Şahbaz N. , Kaya Ö. , Müller-Uri F. Kreis W. Gürel E. :In vitro propagation and cardenolide profiling of Digitalis ferruginea subsp. schischkinii, a medicinally important foxglove species with limited distribution in Northern Turkey In Vitro Cellular & Developmental Biology-Plant 2016 )ISSN: 1054-5476
2015
Mohammed A. , Yücesan B. , Demir-Ordu Ö. , Cihangir C. , Eker İ. , Kreis W. Gürel E. :In vitro regeneration and cardenolide determination of an endemic foxglove, Digitalis cariensis (Aegean Foxglove) In Vitro Cellular & Developmental Biology-Plant 51 2015 ), S. 438-444 ISSN: 1054-5476 10.1007/s11627-015-9697-6 Munkert J. Costa C. Budeanu O. , Petersen J. Bertolucci S. , Fischer G. Müller-Uri F. Kreis W. Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers Plant Biology 17 2015 ), S. 1113-1122 ISSN: 1435-8603 10.1111/plb.12361 Munkert J. Pollier J. , Miettinen K. , Van Moerkercke A. , Payne R. , Müller-Uri F. Burlat V. , O'Connor SE. , Memelink J. , Kreis W. Goossens A. :Iridoid Synthase Activity is Common among the Plant Progesterone 5β-Reductase Family Molecular Plant 8 2015 ), S. 136-152 ISSN: 1674-2052 10.1016/j.molp.2014.11.005 Nolte E. Sobel A. , Wach S. , Hertlein H. , Ebert N. Müller-Uri F. Slany R. Taubert H. Wullich B. Kreis W. The new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) efficiently suppresses cell growth in human leukemia and urologic tumor cell lines Anticancer Research 35 2015 ), S. 5271-5276 ISSN: 0250-7005 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942815459&origin=inward Petersen J. Lanig H. , Munkert J. Bauer P. Müller-Uri F. Kreis W. Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations Journal of Biomolecular Structure & Dynamics 2015 ), S. 1-14 ISSN: 0739-1102 10.1080/07391102.2015.1088797 Schneider NFZ. , Geller FC. , Persich L. , Marostica LL. , Maia de Pádua R. , Kreis W. Braga FC. , Simões CMO. :Inhibition of cell proliferation, invasion and migration by the cardenolides digitoxigenin monodigitoxoside and convallatoxin in human lung cancer cell line Natural Product Research 2015 ), S. 1-5 ISSN: 1478-6419 10.1080/14786419.2015.1055265
2014
Kreis W. Haug B. , Yücesan B. :Somaclonal variation of cardenolide content in Heywood's foxglove, a source for the antiviral cardenolide glucoevatromonoside, regenerated from permanent shoot culture and callus In Vitro Cellular & Developmental Biology-Plant 51 2014 ), S. 35-41 ISSN: 1054-5476 10.1007/s11627-014-9642-0 Loebers A. Müller-Uri F. Kreis W. A young root-specific gene (ArMY2) from horseradish encoding a MYR II myrosinase with kinetic perference for the root-specific glucosinolate gluconasturtiin Phytochemistry 99 2014 ), S. 26-35 ISSN: 0031-9422 10.1016/j.phytochem.2013.11.008 Meitinger N. Geiger D. Augusto TW. , Maia de Pádua R. , Kreis W. Purification of Δ(5)-3-ketosteroid isomerase from Digitalis lanata Phytochemistry 109 2014 ), S. 6-13 ISSN: 0031-9422 10.1016/j.phytochem.2014.10.025 Munkert J. Ernst M. Müller-Uri F. Kreis W. Identification and stress-induced expression of three 3β-hydroxysteroid dehydrogenases from Erysimum crepidifolium Rchb. and their putative role in cardenolide biosynthesis Phytochemistry 100 2014 ), S. 26-33 ISSN: 0031-9422 10.1016/j.phytochem.2014.01.006 Rudolph K. Bauer P. Schmid B. Müller-Uri F. Kreis W. Truncation of N-terminal regions of Digitalis lanata progesterone 5β-reductase alters catalytic efficiency and substrate preference Biochimie 101 2014 ), S. 31-38 ISSN: 0300-9084 10.1016/j.biochi.2013.12.010
2013
Kreis W. Müller-Uri F. Cardenolide aglycone formation in Digitalis In: Bach Thomas J., Rohmer Michel (Hrsg.): Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches New York Springer Science + Business Media 2013 , S. 425-438 ISBN: 978-1-4614-4062-8 10.1007/978-1-4614-4063-5_29 Scheer R. , Alban S. , Becker H. , Blaschek W. , Kemper F. , Kreis W. Matthes H. , Schilcher H. , Stange R. (Hrsg.):Die Mistel in der Tumortherapie 3. Aktueller Stand der Forschung und klinische Anwendung Essen 2013 ISBN: 978-3-86864-032-8 Yücesan B. , Müller-Uri F. Kreis W. Gürel E. :Cardenolide estimation in callus-mediated regenerants of Digitalis lamarckii Ivanina (dwarf foxglove) In Vitro Cellular & Developmental Biology-Plant 50 2013 ), S. 137-142 ISSN: 1054-5476 10.1007/s11627-013-9549-1
2012
Bauer P. Rudolph K. Müller-Uri F. Kreis W. Vein Patterning 1-encoded progesterone 5beta-reductase: Activity-guided improvement of catalytic efficiency Phytochemistry 77 2012 ), S. 53-59 ISSN: 0031-9422 10.1016/j.phytochem.2012.01.022 Durchschein K. , Wallner S. , Macheroux P. , Schwab W. , Winkler T. , Kreis W. Faber K. :Nicotinamide-Dependent Ene Reductases as Alternative Biocatalysts for the Reduction of Activated Alkenes European Journal of Organic Chemistry 2012 2012 ), S. 4963-4968 ISSN: 1434-193X 10.1002/ejoc.201200776 Maia de Pádua R. , Meitinger N. de Souza Filho JD. , Waibel R. Gmeiner P. Braga FC. , Kreis W. Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W.1.4) Steroids 77 2012 ), S. 1373-1380 ISSN: 0039-128X 10.1016/j.steroids.2012.07.016
2011
Bauer P. Kreis W. Curcumin in der Krebstherapie Deutsche Zeitschrift für Onkologie 41 2011 ), S. 144-149 ISSN: 0931-0037 10.1055/s-0030-1257694 Bauer P. Müller-Uri F. Kreis W. Burda E. , Munkert J. Progesterone 5β-reductase of Erysimum crepidifolium: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant protein Phytochemistry 72 2011 ), S. 1710-1717 ISSN: 0031-9422 10.1016/j.phytochem.2011.06.007 Bertol JW. , Rigotto C. , Maia de Pádua R. , Kreis W. Barardi CRM. , Braga FC. , Simões CMO. :Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata. Antiviral Research 92 2011 ), S. 73-90 ISSN: 0166-3542 10.1016/j.antiviral.2011.06.015 Clemente ES. , Müller-Uri F. Nebauer SG. , Segura J. , Kreis W. Arrillaga I. :Digitalis In: Kole Chittaranjan (Hrsg.): Wild Crop Relatives: Genomic and Breeding Resources, Plantaton and Ornamental Crops Berlin Heidelberg Springer 2011 , S. 73-112 ISBN: 978-3-642-21201-7 10.1007/978-3-642-21200-0
2010
Bauer P. Munkert J. Brydziun M. , Burda E. , Müller-Uri F. Gröger H. , Muller Y. Kreis W. Highly conserved progesterone 5β-reductase (P5βR) genes, from 5β-cardenolide-free and 5β-cardenolide-producing angiosperms. Phytochemistry 71 2010 ), S. 1495-1505 ISSN: 0031-9422 10.1016/j.phytochem.2010.06.004 Baumgertel A. , Loebers A. Kreis W. Buckwheat is a Source for the Herbal Drug Fagopyri herba: Rutin Content and Activity of Flavonoid-Degrading Enzymes during Plant Development. The European Journal of Plant Science and Biotechnology Special Issue 1 2010 ), S. 82-86 ISSN: 1752-3842 Kreis W. Enzyme bei der Gewinnung von Drogen und der Herstellung von Phytopharmaka. In: Hänsel Rudolf, Sticher Otto (Hrsg.): Pharmakognosie - Phytopharmazie Berlin Heidelberg NY Springer 2010 , S. 273-279 ISBN: 978-3-642-00962-4 Kreis W. Prinzipien des Sekundärstoffwechsels In: Hänsel Rudolf, Sticher Otto (Hrsg.): Pharmakognosie - Phytopharmazie Belin, Heidelberg, New York Springer 2010 , S. 3-27 ISBN: 978-3-642-00962-4 Kreis W. Müller-Uri F. Biochemistry of sterols, cardiac glycosides, brassinosteroids, phytoecdysteroids and steroid saponins In: Wink M (Hrsg.): Biochemistry of Plant Secondary Metabolism. Annual Review Plant Sheffield CRC Press 2010 , S. 304-363 ISBN: 9781405183970 10.1002/9781444320503.ch6 Müller-Uri F. Kreis W. Recent Advances in Cardenolide Research. In: Journal of Academy of Sciences of Moldova (Hrsg.): Buletinul Academiei de Stiinte a Moldovei Chisinau 2010 , S. 45-52
