Biogenic avenues towards infection and antiinflammatory therapy

The combination of incorrect and overly frequent application of antibiotics and insufficient hygiene measures in hospitals leads to a worldwide rise in the number of resistant bacteria for which ever less effective therapies exist. At the Chair for Pharmaceutical Biology intelligent mechanisms of action and nano-systems that transport known antibiotics to infected sites in the human body are explored. We apply state-of-the-art biomimetic systems that utilise mechanisms found in nature or are derived from them. This allows for an effective control of pathogenic bacteria with minimal adverse effects. … >


Extracellular vesicles

Our focus is on the characterisation of extracellular vesicles (EVs) as natural conveyers of cellular information. EVs are nanoparticles of 50-200 nm in size that are produced naturally by virtually all eukaryotic and prokaryotic cells. EVs consists of a lipid double layer, carry signal molecules, such as proteins or nucleic acids (e.g. microRNA), and are very efficient cell-cell communicators that migrate from one cell type to another, interact with the target cell by means of their surface and membrane proteins and thus transfer signal molecules in a highly specific manner. … >


Cardenolides in tumor therapy

Cardiac glycosides are a group of natural products that share a steroid-like structure with an unsaturated lactone ring. They induce cardiontonic effects by inhibiting Na + /K + -ATPase. Cardiac glycosides have been used traditionally in the treatment of congestive heart failure. More recent studies suggested that cardiac glycosides may also be useful in cancer therapy as they inhibit cell proliferation and cancer cell growth at nanomolar concentrations. The underlying molecular mechanisms are still … >

Plant cell and tissue culture

Different techniques of micropropagation can be used for the maintenance, propagation, and cloning of important medicinal plants. We apply the following methods to solve different problems (conservation, propagation, and biochemical studies): In-vitro-cloning of valuable unique plants by meristem-cultures, Callus cultivation aiming at organogenesis, Permanent cell and tissue cultures. >