Junior Research Group: Bacterial Interface Dynamics

Vilhena lab -Bacterial Interface Dynamics

Welcome to the Vilhena Lab! Our lab investigates the dynamic interactions between Streptococcus pneumoniae and its environment, with a specific focus on the formation and function of bacterial extracellular vesicles (EVs). EVs are not only essential for intercellular communication but also play crucial roles in infection and immune evasion. Investigating their biogenesis will facilitate downstream bioengineering applications.

Key Research Areas:

– Biogenesis of S. pneumoniae EVs

We explore how EVs are formed under various environmental stimuli, such as an infection scenario or varying nutrient availability. Using molecular biology, biochemistry, and super-resolution microscopy, we aim to reveal the molecular machinery driving vesicle production and their role in bacterial survival and adaptation.

– Biological Processes & Metabolic Cost of EVs Formation

Our lab employs advanced single-cell and single-molecule techniques to understand how S. pneumoniae allocates resources for EVs formation. We investigate the metabolic cost of this process and its effect on key cellular mechanisms, such as protein allocation to the cell wall.

– Host-Pathogen Interactions & EV Dynamics

Leveraging confocal microscopy and infection models, we study how S. pneumoniae interacts with host cells. We look at how EVs mediate these interactions, facilitating immune evasion, modulating the host response and how does the bacterial surface architecture dynamically rearranges.

At the Vilhena Lab, we are committed to fostering a diverse, inclusive, and respectful environment. We believe that innovation thrives in a setting where all voices are heard and respected, regardless of background, gender, ethnicity, or identity. Our lab culture emphasizes collaboration, kindness, and mutual respect, ensuring that everyone can contribute meaningfully to our shared scientific goals.

We are open to interdisciplinary approaches, welcoming collaborations that integrate computational biology, systems biology, mathematics and even arts!

We always welcome motivated students. Feel free to email us at claudia.vilhena@fau.de to inquire about open positions.

For more updates go to https://singlecell-vilhena.website2.me/