Jennifer Munkert
2022
De Padua RM. , Kratz JM. , Munkert J. , Bertol JW. , Rigotto C. , Schuster D. , Maltarollo VG. , Kreis W. , Oliveira Simoes CM. , Braga FC. :Effects of Lipophilicity and Structural Features on the Antiherpes Activity of Digitalis Cardenolides and Derivatives Chemistry & Biodiversity 2022 )ISSN: 1612-1872 10.1002/cbdv.202200411 Klein J. , Ernst M. , Christmann A. , Tropper M. , Leykauf T. , Kreis W. , Munkert J. :Knockout of arabidopsis thaliana vep1, encoding a prise (Progesterone 5β-reductase/iridoid synthase-like enzyme), leads to metabolic changes in response to exogenous methyl vinyl ketone (mvk) Metabolites 12 2022 ), Art.Nr.: 11 ISSN: 2218-1989 10.3390/metabo12010011
2021
Dorfner M. , Klein J. , Lanig H. , Kreis W. , Munkert J. :Identifying structural features for changing substrate preferences in two Plantago PRISEs (pro-gesterone 5 beta-reductase and / or iridoid synthase) In: PLANTA MEDICA , STUTTGART 2021 10.1055/s-0041-1736952 Ignatova A. , Klein J. , Leykauf T. , Kreis W. , Munkert J. :Restoring cardenolide accumulation in RNAi-mediated DlP5 beta R1 and DlP5 beta R2 knockdown shoot culture lines of Digitalis lanata and studying the effects of precursor feeding on cardenolide free dark-cultured D. lanata shoots In: PLANTA MEDICA , STUTTGART 2021 10.1055/s-0041-1736902 Klein J. , Horn E. , Ernst M. , Leykauf T. , Leupold T. , Dorfner M. , Wolf LS. , Ignatova A. , Kreis W. , Munkert J. :RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content Plant Cell Reports 2021 )ISSN: 0721-7714 10.1007/s00299-021-02707-3 Leykauf T. , Klein J. , Lodel M. , Kreis W. , Munkert J. :Overexpression of 3 beta-hydroxysteroid dehydrogenases in Digitalis lanata shoot cultures In: PLANTA MEDICA , STUTTGART 2021 10.1055/s-0041-1736957 Tropper M. , Höhn S. , Wolf LS. , Fritsch J. , Kastner-Detter N. , Rieck C. , Munkert J. , Meitinger N. , Lanig H. , Kreis W. :21-Hydroxypregnane 21-O-malonylation, a crucial step in cardenolide biosynthesis, can be achieved by substrate-promiscuous BAHD-type phenolic glucoside malonyltransferases from Arabidopsis thaliana and homolog proteins from Digitalis lanata Phytochemistry 187 2021 ), Art.Nr.: 112710 ISSN: 0031-9422 10.1016/j.phytochem.2021.112710 Zanchett Schneider NF. , Menegaz D. , Andreotti Dagostin AL. , Persich L. , Rocha SC. , Pacheco Ramos AC. , Cortes VF. , Leite Fontes CF. , De Padua RM. , Munkert J. , Kreis W. , Braga FC. , Barbosa LA. , Mena Barreto Silva FR. , Oliveira Simoes CM. :Cytotoxicity of glucoevatromonoside alone and in combination with chemotherapy drugs and their effects on Na+,K+-ATPase and ion channels on lung cancer cells Molecular and Cellular Biochemistry 2021 )ISSN: 0300-8177 10.1007/s11010-020-04040-x
2020
Boff L. , Persich L. , Brambila P. , Ottoni FM. , Munkert J. , Ramos GS. , Soares Viana AR. , Kreis W. , Braga FC. , Alves RJ. , Maia de Pádua R. , Schneider NFZ. , Simões CMO. :Investigation of the cytotoxic activity of two novel digitoxigenin analogues on H460 lung cancer cells Anti-Cancer Drugs 31 2020 ), S. 452-462 ISSN: 0959-4973 10.1097/CAD.0000000000000872 Boff L. , Schneider NFZ. , Munkert J. , Ottoni FM. , Ramos GS. , Kreis W. , Braga FC. , Alves RJ. , Maia de Pádua R. , Simões CMO. :Elucidation of the mechanism of anti-herpes action of two novel semisynthetic cardenolide derivatives. Archives of Virology 2020 ), S. 1385-1396 ISSN: 0304-8608 10.1007/s00705-020-04562-1 Boff L. , Schreiber A. , Matos AdR. , Del Sarto JL. , Brunotte L. , Munkert J. , Ottoni FM. , Ramos GS. , Kreis W. , Braga FC. , Alves RJ. , Maia de Pádua R. , Simões CMO. , Ludwig S. :Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation Molecules 2020 )ISSN: 1420-3049 10.3390/molecules25204853 Freitas CS. , Oliveira-da-Silva JA. , Lage DP. , Costa RR. , Mendonça DV. , Martins VT. , Reis TA. , Antinarelli LM. , Machado AS. , Tavares GS. , Ramos FF. , Coelho VT. , Brito RC. , Ludolf F. , Chávez-Fumagalli MA. , Roatt BM. , Ramos GS. , Munkert J. , Ottoni FM. , Campana PR. , Humbert MV. , Coimbra ES. , Braga FC. , Pádua RM. , Coelho EA. :Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis Parasitology Research 2020 )ISSN: 0932-0113 10.1007/s00436-020-06971-2 Horn E. , Kemmler Y. , Kreis W. , Munkert J. :Cardenolide and glucosinolate accumulation in shoot cultures of Erysimum crepidifolium Rchb. In Vitro Cellular & Developmental Biology-Plant 2020 )ISSN: 1054-5476 10.1007/s11627-020-10135-3
2019
Boff L. , Munkert J. , Ottoni FM. , Schneider NFZ. , Ramos GS. , Kreis W. , Andrade SF. , De Souza Filho JD. , Braga FC. , Alves RJ. , De Padua RM. , Simões CMO. :Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives European Journal of Medicinal Chemistry 167 2019 ), S. 546-561 ISSN: 0223-5234 10.1016/j.ejmech.2019.01.076 Boff L. , Munkert J. , Ottoni FM. , Zanchett Schneider NF. , Ramos GS. , Kreis W. , De Andrade SF. , Dias De Souza Filho J. , Castro Braga F. , Alves RJ. , Maia De Padua R. , Simões CMO. :Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399709 Kreis W. , Munkert J. :Exploiting enzyme promiscuity to shape plant specialized metabolism Journal of Experimental Botany 70 2019 ), S. 1435-1445 ISSN: 0022-0957 10.1093/jxb/erz025 Leykauf T. , Klein J. , Ernst M. , Kreis W. , Munkert J. :RNAi mediated knock down of 3 beta-hydroxysteroid dehydrogenases in Digitalis lanata shoot cultures 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399800 Munkert J. , Gomes ER. , Marostica LL. , Cota BB. , Lopes CL. , Andrade SF. , Filho JDS. , Alves RJ. , Oliveira MC. , Braga FC. , Simões CM. , Pádua RM. , De Barros AL. :New 99mTc-Labeled Digitoxigenin Derivative for Cancer Cell Identification ACS Omega 2019 )ISSN: 2470-1343 10.1021/acsomega.9b03167 Rieck C. , Geiger D. , Munkert J. , Messerschmidt K. , Petersen J. , Strasser J. , Meitinger N. , Kreis W. :Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae MicrobiologyOpen 2019 ), Art.Nr.: e925 ISSN: 2045-8827 10.1002/mbo3.925 Tropper M. , Höhn S. , Munkert J. , Kreis W. :BAHD-like malonyltransferase genes from Digitalis lanata and Arabidopsis thaliana and their putative role in cardenolide biosynthesis 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399788
2018
Gomes ER. , Novais MVM. , Silva IT. , Barros ALB. , Leite EA. , Munkert J. , Frade ACM. , Cassali GD. , Braga FC. , De Padua RM. , Oliveira MC. :Long-circulating and fusogenic liposomes loaded with a glucoevatromomoside derivative induce potent antitumor response Biomedicine & Pharmacotherapy 2018 ), S. 1152 - 1161 ISSN: 0753-3322 10.1016/j.biopha.2018.09.109 Schmidt K. , Petersen J. , Munkert J. , Egerer-Sieber C. , Hornig M. , Muller Y. , Kreis W. :PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism. Phytochemistry 156 2018 ), S. 9-19 ISSN: 0031-9422 10.1016/j.phytochem.2018.08.012 Schneider NFZ. , Cerella C. , Lee JY. , Mazumder A. , Kim KR. , de Carvalho A. , Munkert J. , De Padua RM. , Kreis W. , Kim KW. , Christov C. , Dicato M. , Kim HJ. , Han BW. , Braga FC. , Simões CMO. , Diederich M. :Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-specific Cell Death Frontiers in Pharmacology 9 2018 ), Art.Nr.: 70 ISSN: 1663-9812 10.3389/fphar.2018.00070 Silva IT. , Munkert J. , Nolte E. , Schneider NFZ. , Rocha SC. , Ramos ACP. , Kreis W. , Braga FC. , De Padua RM. , Taranto AG. , Cortes VF. , Barbosa LA. , Wach S. , Taubert H. , Simões CMO. :Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+ -ATPase inhibition. Biomedicine & Pharmacotherapy 107 2018 ), S. 464-474 ISSN: 0753-3322 10.1016/j.biopha.2018.08.028
2017
Kreis W. , Munkert J. , De Padua RM. :Biossíntese de metabólitos primários e secundários In: Letícia Bispo de Lima (Hrsg.): Farmacognosia do Produto Natural ao Medicamento Porto Alegre, Brazil Artmed Editora Ltda. 2017 , S. 147 - 166 ISBN: 978-85-8271-359-4 Munkert J. , Kreis W. :Herzglykoside und ihr Potenzial für die Tumortherapie Deutsche Zeitschrift für Onkologie 49 2017 ), S. 129-135 ISSN: 0931-0037 10.1055/s-0043-115681 Munkert J. , Santiago Franco M. , Nolte E. , Silva IT. , Oliveira Castilho R. , Ottoni FM. , Schneider NFZ. , Oliveira MC. , Taubert H. , Bauer W. , Andrade SF. , Alves RJ. , Simões CMO. , Braga FC. , Kreis W. , De Padua RM. :Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture. Planta medica 2017 )ISSN: 1439-0221 10.1055/s-0043-109557 Nolte E. , Wach S. , Silva IT. , Lukat S. , Ekici AB. , Munkert J. , Müller-Uri F. , Kreis W. , Simões CMO. , Vera González J. , Wullich B. , Taubert H. , Lai X. :A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines Oncotarget 8 2017 ), S. 11676-11691 ISSN: 1949-2553 10.18632/oncotarget.14644 Schneider NFZ. , Persich L. , Rocha SC. , Ramos ACP. , Cortes VF. , Silva IT. , Munkert J. , De Padua RM. , Kreis W. , Taranto AG. , Barbosa LA. , Braga FC. , Simões CMO. :Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase Biomedicine & Pharmacotherapy 97 2017 ), S. 684-696 ISSN: 0753-3322 10.1016/j.biopha.2017.10.128
2016
2015
Ernst M. , Munkert J. , Campa M. , Malnoy M. , Martens S. , Müller-Uri F. :Steroid 5β-reductase from leaves of Vitis vinifera: molecular cloning, expression and modelling Journal of Agricultural and Food Chemistry 63 2015 ), S. 10112–10120 ISSN: 0021-8561 10.1021/acs.jafc.5b04261 Munkert J. , Costa C. , Budeanu O. , Petersen J. , Bertolucci S. , Fischer G. , Müller-Uri F. , Kreis W. :Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers Plant Biology 17 2015 ), S. 1113-1122 ISSN: 1435-8603 10.1111/plb.12361 Munkert J. , Pollier J. , Miettinen K. , Van Moerkercke A. , Payne R. , Müller-Uri F. , Burlat V. , O'Connor SE. , Memelink J. , Kreis W. , Goossens A. :Iridoid Synthase Activity is Common among the Plant Progesterone 5β-Reductase Family Molecular Plant 8 2015 ), S. 136-152 ISSN: 1674-2052 10.1016/j.molp.2014.11.005 Petersen J. , Lanig H. , Munkert J. , Bauer P. , Müller-Uri F. , Kreis W. :Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations Journal of Biomolecular Structure & Dynamics 2015 ), S. 1-14 ISSN: 0739-1102 10.1080/07391102.2015.1088797
2014
2011
2010
