Jennifer Munkert
2022
2021
- Dorfner M., Klein J., Lanig H., Kreis W., Munkert J.:
Identifying structural features for changing substrate preferences in two Plantago PRISEs (pro-gesterone 5 beta-reductase and / or iridoid synthase)
In: PLANTA MEDICA, STUTTGART: 2021
DOI: 10.1055/s-0041-1736952
- Ignatova A., Klein J., Leykauf T., Kreis W., Munkert J.:
Restoring cardenolide accumulation in RNAi-mediated DlP5 beta R1 and DlP5 beta R2 knockdown shoot culture lines of Digitalis lanata and studying the effects of precursor feeding on cardenolide free dark-cultured D. lanata shoots
In: PLANTA MEDICA, STUTTGART: 2021
DOI: 10.1055/s-0041-1736902
- Klein J., Horn E., Ernst M., Leykauf T., Leupold T., Dorfner M., Wolf LS., Ignatova A., Kreis W., Munkert J.:
RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content
In: Plant Cell Reports (2021)
ISSN: 0721-7714
DOI: 10.1007/s00299-021-02707-3
- Tropper M., Höhn S., Wolf LS., Fritsch J., Kastner-Detter N., Rieck C., Munkert J., Meitinger N., Lanig H., Kreis W.:
21-Hydroxypregnane 21-O-malonylation, a crucial step in cardenolide biosynthesis, can be achieved by substrate-promiscuous BAHD-type phenolic glucoside malonyltransferases from Arabidopsis thaliana and homolog proteins from Digitalis lanata
In: Phytochemistry 187 (2021), Art.Nr.: 112710
ISSN: 0031-9422
DOI: 10.1016/j.phytochem.2021.112710
- Zanchett Schneider NF., Menegaz D., Andreotti Dagostin AL., Persich L., Rocha SC., Pacheco Ramos AC., Cortes VF., Leite Fontes CF., De Padua RM., Munkert J., Kreis W., Braga FC., Barbosa LA., Mena Barreto Silva FR., Oliveira Simoes CM.:
Cytotoxicity of glucoevatromonoside alone and in combination with chemotherapy drugs and their effects on Na+,K+-ATPase and ion channels on lung cancer cells
In: Molecular and Cellular Biochemistry (2021)
ISSN: 0300-8177
DOI: 10.1007/s11010-020-04040-x
2020
- Boff L., Persich L., Brambila P., Ottoni FM., Munkert J., Ramos GS., Soares Viana AR., Kreis W., Braga FC., Alves RJ., Maia de Pádua R., Schneider NFZ., Simões CMO.:
Investigation of the cytotoxic activity of two novel digitoxigenin analogues on H460 lung cancer cells
In: Anti-Cancer Drugs 31 (2020), S. 452-462
ISSN: 0959-4973
DOI: 10.1097/CAD.0000000000000872
- Boff L., Schneider NFZ., Munkert J., Ottoni FM., Ramos GS., Kreis W., Braga FC., Alves RJ., Maia de Pádua R., Simões CMO.:
Elucidation of the mechanism of anti-herpes action of two novel semisynthetic cardenolide derivatives.
In: Archives of Virology (2020), S. 1385-1396
ISSN: 0304-8608
DOI: 10.1007/s00705-020-04562-1
- Boff L., Schreiber A., Matos AdR., Del Sarto JL., Brunotte L., Munkert J., Ottoni FM., Ramos GS., Kreis W., Braga FC., Alves RJ., Maia de Pádua R., Simões CMO., Ludwig S.:
Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation
In: Molecules (2020)
ISSN: 1420-3049
DOI: 10.3390/molecules25204853
- Freitas CS., Oliveira-da-Silva JA., Lage DP., Costa RR., Mendonça DV., Martins VT., Reis TA., Antinarelli LM., Machado AS., Tavares GS., Ramos FF., Coelho VT., Brito RC., Ludolf F., Chávez-Fumagalli MA., Roatt BM., Ramos GS., Munkert J., Ottoni FM., Campana PR., Humbert MV., Coimbra ES., Braga FC., Pádua RM., Coelho EA.:
Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis
In: Parasitology Research (2020)
ISSN: 0932-0113
DOI: 10.1007/s00436-020-06971-2
- Horn E., Kemmler Y., Kreis W., Munkert J.:
Cardenolide and glucosinolate accumulation in shoot cultures of Erysimum crepidifolium Rchb.
In: In Vitro Cellular & Developmental Biology-Plant (2020)
ISSN: 1054-5476
DOI: 10.1007/s11627-020-10135-3
2019
- Boff L., Munkert J., Ottoni FM., Schneider NFZ., Ramos GS., Kreis W., Andrade SF., De Souza Filho JD., Braga FC., Alves RJ., De Padua RM., Simões CMO.:
Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives
In: European Journal of Medicinal Chemistry 167 (2019), S. 546-561
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2019.01.076
- Boff L., Munkert J., Ottoni FM., Zanchett Schneider NF., Ramos GS., Kreis W., De Andrade SF., Dias De Souza Filho J., Castro Braga F., Alves RJ., Maia De Padua R., Simões CMO.:
Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives
67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck, 1. September 2019 - 5. September 2019)
In: PLANTA MEDICA, STUTTGART: 2019
DOI: 10.1055/s-0039-3399709
- Kreis W., Munkert J.:
Exploiting enzyme promiscuity to shape plant specialized metabolism
In: Journal of Experimental Botany 70 (2019), S. 1435-1445
ISSN: 0022-0957
DOI: 10.1093/jxb/erz025
- Leykauf T., Klein J., Ernst M., Kreis W., Munkert J.:
RNAi mediated knock down of 3 beta-hydroxysteroid dehydrogenases in Digitalis lanata shoot cultures
67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck, 1. September 2019 - 5. September 2019)
In: PLANTA MEDICA, STUTTGART: 2019
DOI: 10.1055/s-0039-3399800
- Munkert J., Gomes ER., Marostica LL., Cota BB., Lopes CL., Andrade SF., Filho JDS., Alves RJ., Oliveira MC., Braga FC., Simões CM., Pádua RM., De Barros AL.:
New 99mTc-Labeled Digitoxigenin Derivative for Cancer Cell Identification
In: ACS Omega (2019)
ISSN: 2470-1343
DOI: 10.1021/acsomega.9b03167
- Rieck C., Geiger D., Munkert J., Messerschmidt K., Petersen J., Strasser J., Meitinger N., Kreis W.:
Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae
In: MicrobiologyOpen (2019), Art.Nr.: e925
ISSN: 2045-8827
DOI: 10.1002/mbo3.925
- Tropper M., Höhn S., Munkert J., Kreis W.:
BAHD-like malonyltransferase genes from Digitalis lanata and Arabidopsis thaliana and their putative role in cardenolide biosynthesis
67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck, 1. September 2019 - 5. September 2019)
In: PLANTA MEDICA, STUTTGART: 2019
DOI: 10.1055/s-0039-3399788
2018
- Gomes ER., Novais MVM., Silva IT., Barros ALB., Leite EA., Munkert J., Frade ACM., Cassali GD., Braga FC., De Padua RM., Oliveira MC.:
Long-circulating and fusogenic liposomes loaded with a glucoevatromomoside derivative induce potent antitumor response
In: Biomedicine & Pharmacotherapy (2018), S. 1152 - 1161
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2018.09.109
- Schmidt K., Petersen J., Munkert J., Egerer-Sieber C., Hornig M., Muller Y., Kreis W.:
PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism.
In: Phytochemistry 156 (2018), S. 9-19
ISSN: 0031-9422
DOI: 10.1016/j.phytochem.2018.08.012
- Schneider NFZ., Cerella C., Lee JY., Mazumder A., Kim KR., de Carvalho A., Munkert J., De Padua RM., Kreis W., Kim KW., Christov C., Dicato M., Kim HJ., Han BW., Braga FC., Simões CMO., Diederich M.:
Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-specific Cell Death
In: Frontiers in Pharmacology 9 (2018), Art.Nr.: 70
ISSN: 1663-9812
DOI: 10.3389/fphar.2018.00070
- Silva IT., Munkert J., Nolte E., Schneider NFZ., Rocha SC., Ramos ACP., Kreis W., Braga FC., De Padua RM., Taranto AG., Cortes VF., Barbosa LA., Wach S., Taubert H., Simões CMO.:
Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+ -ATPase inhibition.
In: Biomedicine & Pharmacotherapy 107 (2018), S. 464-474
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2018.08.028
2017
- Kreis W., Munkert J., De Padua RM.:
Biossíntese de metabólitos primários e secundários
In: Letícia Bispo de Lima (Hrsg.): Farmacognosia do Produto Natural ao Medicamento, Porto Alegre, Brazil: Artmed Editora Ltda., 2017, S. 147 - 166
ISBN: 978-85-8271-359-4
- Munkert J., Kreis W.:
Herzglykoside und ihr Potenzial für die Tumortherapie
In: Deutsche Zeitschrift für Onkologie 49 (2017), S. 129-135
ISSN: 0931-0037
DOI: 10.1055/s-0043-115681
- Munkert J., Santiago Franco M., Nolte E., Silva IT., Oliveira Castilho R., Ottoni FM., Schneider NFZ., Oliveira MC., Taubert H., Bauer W., Andrade SF., Alves RJ., Simões CMO., Braga FC., Kreis W., De Padua RM.:
Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture.
In: Planta medica (2017)
ISSN: 1439-0221
DOI: 10.1055/s-0043-109557
- Nolte E., Wach S., Silva IT., Lukat S., Ekici AB., Munkert J., Müller-Uri F., Kreis W., Simões CMO., Vera González J., Wullich B., Taubert H., Lai X.:
A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines
In: Oncotarget 8 (2017), S. 11676-11691
ISSN: 1949-2553
DOI: 10.18632/oncotarget.14644
- Schneider NFZ., Persich L., Rocha SC., Ramos ACP., Cortes VF., Silva IT., Munkert J., De Padua RM., Kreis W., Taranto AG., Barbosa LA., Braga FC., Simões CMO.:
Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase
In: Biomedicine & Pharmacotherapy 97 (2017), S. 684-696
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2017.10.128
2016
2015
- Ernst M., Munkert J., Campa M., Malnoy M., Martens S., Müller-Uri F.:
Steroid 5β-reductase from leaves of Vitis vinifera: molecular cloning, expression and modelling
In: Journal of Agricultural and Food Chemistry 63 (2015), S. 10112–10120
ISSN: 0021-8561
DOI: 10.1021/acs.jafc.5b04261
- Munkert J., Costa C., Budeanu O., Petersen J., Bertolucci S., Fischer G., Müller-Uri F., Kreis W.:
Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers
In: Plant Biology 17 (2015), S. 1113-1122
ISSN: 1435-8603
DOI: 10.1111/plb.12361
- Munkert J., Pollier J., Miettinen K., Van Moerkercke A., Payne R., Müller-Uri F., Burlat V., O'Connor SE., Memelink J., Kreis W., Goossens A.:
Iridoid Synthase Activity is Common among the Plant Progesterone 5β-Reductase Family
In: Molecular Plant 8 (2015), S. 136-152
ISSN: 1674-2052
DOI: 10.1016/j.molp.2014.11.005
- Petersen J., Lanig H., Munkert J., Bauer P., Müller-Uri F., Kreis W.:
Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations
In: Journal of Biomolecular Structure & Dynamics (2015), S. 1-14
ISSN: 0739-1102
DOI: 10.1080/07391102.2015.1088797
2014
2011
2010