Jennifer Munkert
2025 2024 2023 Leykauf T. , Klein J. , Ernst M. , Dorfner M. , Ignatova A. , Kreis W. , Lanig H. , Munkert J. :Overexpression and RNAi-mediated Knockdown of Two 3β-hydroxy-Δ5-steroid dehydrogenase Genes in Digitalis lanata Shoot Cultures Reveal Their Role in Cardenolide Biosynthesis Planta Medica 89 2023 ), S. 833-847 ISSN: 0032-0943 10.1055/a-2074-9186 Marafeli ÉAM. , Chibli LA. , Rocha JPM. , Assis RMAd. , Pinto JEBP. , Pádua RMd. , Kreis W. , Munkert J. , Braga FC. , Bertolucci SKV. :Photoconverting nets affect plant growth and levels of antiviral glucoevatromonoside and total cardenolides in Digitalis mariana ssp. heywoodii (P. Silva and M. Silva) Hinz Industrial Crops and Products 204 2023 ), Art.Nr.: 117348 ISSN: 0926-6690 10.1016/j.indcrop.2023.117348 2022 De Padua RM. , Kratz JM. , Munkert J. , Bertol JW. , Rigotto C. , Schuster D. , Maltarollo VG. , Kreis W. , Oliveira Simoes CM. , Braga FC. :Effects of Lipophilicity and Structural Features on the Antiherpes Activity of Digitalis Cardenolides and Derivatives Chemistry & Biodiversity 2022 )ISSN: 1612-1872 10.1002/cbdv.202200411 Klein J. , Ernst M. , Christmann A. , Tropper M. , Leykauf T. , Kreis W. , Munkert J. :Knockout of arabidopsis thaliana vep1, encoding a prise (Progesterone 5β-reductase/iridoid synthase-like enzyme), leads to metabolic changes in response to exogenous methyl vinyl ketone (mvk) Metabolites 12 2022 ), Art.Nr.: 11 ISSN: 2218-1989 10.3390/metabo12010011 2021 Dorfner M. , Klein J. , Lanig H. , Kreis W. , Munkert J. :Identifying structural features for changing substrate preferences in two Plantago PRISEs (pro-gesterone 5 beta-reductase and / or iridoid synthase) In: PLANTA MEDICA , STUTTGART 2021 10.1055/s-0041-1736952 Ignatova A. , Klein J. , Leykauf T. , Kreis W. , Munkert J. :Restoring cardenolide accumulation in RNAi-mediated DlP5 beta R1 and DlP5 beta R2 knockdown shoot culture lines of Digitalis lanata and studying the effects of precursor feeding on cardenolide free dark-cultured D. lanata shoots In: PLANTA MEDICA , STUTTGART 2021 10.1055/s-0041-1736902 Klein J. , Horn E. , Ernst M. , Leykauf T. , Leupold T. , Dorfner M. , Wolf LS. , Ignatova A. , Kreis W. , Munkert J. :RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content Plant Cell Reports 2021 )ISSN: 0721-7714 10.1007/s00299-021-02707-3 Leykauf T. , Klein J. , Lodel M. , Kreis W. , Munkert J. :Overexpression of 3 beta-hydroxysteroid dehydrogenases in Digitalis lanata shoot cultures In: PLANTA MEDICA , STUTTGART 2021 10.1055/s-0041-1736957 Tropper M. , Höhn S. , Wolf LS. , Fritsch J. , Kastner-Detter N. , Rieck C. , Munkert J. , Meitinger N. , Lanig H. , Kreis W. :21-Hydroxypregnane 21-O-malonylation, a crucial step in cardenolide biosynthesis, can be achieved by substrate-promiscuous BAHD-type phenolic glucoside malonyltransferases from Arabidopsis thaliana and homolog proteins from Digitalis lanata Phytochemistry 187 2021 ), Art.Nr.: 112710 ISSN: 0031-9422 10.1016/j.phytochem.2021.112710 Zanchett Schneider NF. , Menegaz D. , Andreotti Dagostin AL. , Persich L. , Rocha SC. , Pacheco Ramos AC. , Cortes VF. , Leite Fontes CF. , De Padua RM. , Munkert J. , Kreis W. , Braga FC. , Barbosa LA. , Mena Barreto Silva FR. , Oliveira Simoes CM. :Cytotoxicity of glucoevatromonoside alone and in combination with chemotherapy drugs and their effects on Na+,K+-ATPase and ion channels on lung cancer cells Molecular and Cellular Biochemistry 2021 )ISSN: 0300-8177 10.1007/s11010-020-04040-x 2020 Boff L. , Persich L. , Brambila P. , Ottoni FM. , Munkert J. , Ramos GS. , Soares Viana AR. , Kreis W. , Braga FC. , Alves RJ. , Maia de Pádua R. , Schneider NFZ. , Simões CMO. :Investigation of the cytotoxic activity of two novel digitoxigenin analogues on H460 lung cancer cells Anti-Cancer Drugs 31 2020 ), S. 452-462 ISSN: 0959-4973 10.1097/CAD.0000000000000872 Boff L. , Schneider NFZ. , Munkert J. , Ottoni FM. , Ramos GS. , Kreis W. , Braga FC. , Alves RJ. , Maia de Pádua R. , Simões CMO. :Elucidation of the mechanism of anti-herpes action of two novel semisynthetic cardenolide derivatives. Archives of Virology 2020 ), S. 1385-1396 ISSN: 0304-8608 10.1007/s00705-020-04562-1 Boff L. , Schreiber A. , Matos AdR. , Del Sarto JL. , Brunotte L. , Munkert J. , Ottoni FM. , Ramos GS. , Kreis W. , Braga FC. , Alves RJ. , Maia de Pádua R. , Simões CMO. , Ludwig S. :Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation Molecules 2020 )ISSN: 1420-3049 10.3390/molecules25204853 Freitas CS. , Oliveira-da-Silva JA. , Lage DP. , Costa RR. , Mendonça DV. , Martins VT. , Reis TA. , Antinarelli LM. , Machado AS. , Tavares GS. , Ramos FF. , Coelho VT. , Brito RC. , Ludolf F. , Chávez-Fumagalli MA. , Roatt BM. , Ramos GS. , Munkert J. , Ottoni FM. , Campana PR. , Humbert MV. , Coimbra ES. , Braga FC. , Pádua RM. , Coelho EA. :Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis Parasitology Research 2020 )ISSN: 0932-0113 10.1007/s00436-020-06971-2 Horn E. , Kemmler Y. , Kreis W. , Munkert J. :Cardenolide and glucosinolate accumulation in shoot cultures of Erysimum crepidifolium Rchb. In Vitro Cellular & Developmental Biology-Plant 2020 )ISSN: 1054-5476 10.1007/s11627-020-10135-3 2019 Boff L. , Munkert J. , Ottoni FM. , Schneider NFZ. , Ramos GS. , Kreis W. , Andrade SF. , De Souza Filho JD. , Braga FC. , Alves RJ. , De Padua RM. , Simões CMO. :Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives European Journal of Medicinal Chemistry 167 2019 ), S. 546-561 ISSN: 0223-5234 10.1016/j.ejmech.2019.01.076 Boff L. , Munkert J. , Ottoni FM. , Zanchett Schneider NF. , Ramos GS. , Kreis W. , De Andrade SF. , Dias De Souza Filho J. , Castro Braga F. , Alves RJ. , Maia De Padua R. , Simões CMO. :Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399709 Kreis W. , Munkert J. :Exploiting enzyme promiscuity to shape plant specialized metabolism Journal of Experimental Botany 70 2019 ), S. 1435-1445 ISSN: 0022-0957 10.1093/jxb/erz025 Leykauf T. , Klein J. , Ernst M. , Kreis W. , Munkert J. :RNAi mediated knock down of 3 beta-hydroxysteroid dehydrogenases in Digitalis lanata shoot cultures 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399800 Munkert J. , Gomes ER. , Marostica LL. , Cota BB. , Lopes CL. , Andrade SF. , Filho JDS. , Alves RJ. , Oliveira MC. , Braga FC. , Simões CM. , Pádua RM. , De Barros AL. :New 99mTc-Labeled Digitoxigenin Derivative for Cancer Cell Identification ACS Omega 2019 )ISSN: 2470-1343 10.1021/acsomega.9b03167 Rieck C. , Geiger D. , Munkert J. , Messerschmidt K. , Petersen J. , Strasser J. , Meitinger N. , Kreis W. :Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae MicrobiologyOpen 2019 ), Art.Nr.: e925 ISSN: 2045-8827 10.1002/mbo3.925 Tropper M. , Höhn S. , Munkert J. , Kreis W. :BAHD-like malonyltransferase genes from Digitalis lanata and Arabidopsis thaliana and their putative role in cardenolide biosynthesis 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck 1. September 2019 - 5. September 2019 )In: PLANTA MEDICA , STUTTGART 2019 10.1055/s-0039-3399788 2018 Gomes ER. , Novais MVM. , Silva IT. , Barros ALB. , Leite EA. , Munkert J. , Frade ACM. , Cassali GD. , Braga FC. , De Padua RM. , Oliveira MC. :Long-circulating and fusogenic liposomes loaded with a glucoevatromomoside derivative induce potent antitumor response Biomedicine & Pharmacotherapy 2018 ), S. 1152 - 1161 ISSN: 0753-3322 10.1016/j.biopha.2018.09.109 Schmidt K. , Petersen J. , Munkert J. , Egerer-Sieber C. , Hornig M. , Muller Y. , Kreis W. :PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism. Phytochemistry 156 2018 ), S. 9-19 ISSN: 0031-9422 10.1016/j.phytochem.2018.08.012 Schneider NFZ. , Cerella C. , Lee JY. , Mazumder A. , Kim KR. , de Carvalho A. , Munkert J. , De Padua RM. , Kreis W. , Kim KW. , Christov C. , Dicato M. , Kim HJ. , Han BW. , Braga FC. , Simões CMO. , Diederich M. :Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-specific Cell Death Frontiers in Pharmacology 9 2018 ), Art.Nr.: 70 ISSN: 1663-9812 10.3389/fphar.2018.00070 Silva IT. , Munkert J. , Nolte E. , Schneider NFZ. , Rocha SC. , Ramos ACP. , Kreis W. , Braga FC. , De Padua RM. , Taranto AG. , Cortes VF. , Barbosa LA. , Wach S. , Taubert H. , Simões CMO. :Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+ -ATPase inhibition. Biomedicine & Pharmacotherapy 107 2018 ), S. 464-474 ISSN: 0753-3322 10.1016/j.biopha.2018.08.028 2017 Kreis W. , Munkert J. , De Padua RM. :Biossíntese de metabólitos primários e secundários In: Letícia Bispo de Lima (Hrsg.): Farmacognosia do Produto Natural ao Medicamento Porto Alegre, Brazil Artmed Editora Ltda. 2017 , S. 147 - 166 ISBN: 978-85-8271-359-4 Munkert J. , Kreis W. :Herzglykoside und ihr Potenzial für die Tumortherapie Deutsche Zeitschrift für Onkologie 49 2017 ), S. 129-135 ISSN: 0931-0037 10.1055/s-0043-115681 Munkert J. , Santiago Franco M. , Nolte E. , Silva IT. , Oliveira Castilho R. , Ottoni FM. , Schneider NFZ. , Oliveira MC. , Taubert H. , Bauer W. , Andrade SF. , Alves RJ. , Simões CMO. , Braga FC. , Kreis W. , De Padua RM. :Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture. Planta medica 2017 )ISSN: 1439-0221 10.1055/s-0043-109557 Nolte E. , Wach S. , Silva IT. , Lukat S. , Ekici AB. , Munkert J. , Müller-Uri F. , Kreis W. , Simões CMO. , Vera González J. , Wullich B. , Taubert H. , Lai X. :A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines Oncotarget 8 2017 ), S. 11676-11691 ISSN: 1949-2553 10.18632/oncotarget.14644 Schneider NFZ. , Persich L. , Rocha SC. , Ramos ACP. , Cortes VF. , Silva IT. , Munkert J. , De Padua RM. , Kreis W. , Taranto AG. , Barbosa LA. , Braga FC. , Simões CMO. :Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase Biomedicine & Pharmacotherapy 97 2017 ), S. 684-696 ISSN: 0753-3322 10.1016/j.biopha.2017.10.128 2016 2015 Ernst M. , Munkert J. , Campa M. , Malnoy M. , Martens S. , Müller-Uri F. :Steroid 5β-reductase from leaves of Vitis vinifera: molecular cloning, expression and modelling Journal of Agricultural and Food Chemistry 63 2015 ), S. 10112–10120 ISSN: 0021-8561 10.1021/acs.jafc.5b04261 Munkert J. , Costa C. , Budeanu O. , Petersen J. , Bertolucci S. , Fischer G. , Müller-Uri F. , Kreis W. :Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers Plant Biology 17 2015 ), S. 1113-1122 ISSN: 1435-8603 10.1111/plb.12361 Munkert J. , Pollier J. , Miettinen K. , Van Moerkercke A. , Payne R. , Müller-Uri F. , Burlat V. , O'Connor SE. , Memelink J. , Kreis W. , Goossens A. :Iridoid Synthase Activity is Common among the Plant Progesterone 5β-Reductase Family Molecular Plant 8 2015 ), S. 136-152 ISSN: 1674-2052 10.1016/j.molp.2014.11.005 Petersen J. , Lanig H. , Munkert J. , Bauer P. , Müller-Uri F. , Kreis W. :Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations Journal of Biomolecular Structure & Dynamics 2015 ), S. 1-14 ISSN: 0739-1102 10.1080/07391102.2015.1088797 2014 2011 2010