Prof. Dr. Wolfgang Kreis

2024

• Dorfner M., Klein J., Senkleiter K., Lanig H., Kreis W., Munkert J.:
  Addressing the Evolution of Cardenolide Formation in Iridoid-Synthesizing Plants: Site-Directed Mutagenesis of PRISEs (Progesterone-5β-Reductase/Iridoid Synthase-like Enzymes) of Plantago Species
  In: Molecules 29 (2024), Art.Nr.: 5788
  ISSN: 1420-3049
  DOI: 10.3390/molecules29235788

2023

• Leykauf T., Klein J., Ernst M., Dorfner M., Ignatova A., Kreis W., Lanig H., Munkert J.:
  Overexpression and RNAi-mediated Knockdown of Two 3β-hydroxy-Δ5-steroid dehydrogenase Genes in Digitalis lanata Shoot Cultures Reveal Their Role in Cardenolide Biosynthesis
  In: Planta Medica 89 (2023), S. 833-847
  ISSN: 0032-0943
  DOI: 10.1055/a-2074-9186
• Marafeli ÉAM., Chibli LA., Rocha JPM., Assis RMAd., Pinto JEBP., Pádua RMd., Kreis W., Munkert J., Braga FC., Bertolucci SKV.:
  Photoconverting nets affect plant growth and levels of antiviral glucoevatromonoside and total cardenolides in Digitalis mariana ssp. heywoodii (P. Silva and M. Silva) Hinz
  In: Industrial Crops and Products 204 (2023), Art.Nr.: 117348
  ISSN: 0926-6690
  DOI: 10.1016/j.indcrop.2023.117348

2022

• Da Silva GM., Mohamed A., De Carvalho AA., Brasil Pereira Pinto JE., Braga FC., De Padua RM., Kreis W., Vilela Bertolucci SK.:
  Influence of the wavelength and intensity of LED lights and cytokinins on the growth rate and the concentration of total cardenolides in Digitalis mariana Boiss. ssp. heywoodii (P. Silva and M. Silva) Hinz cultivated in vitro
  In: Plant Cell Tissue and Organ Culture (2022)
  ISSN: 0167-6857
  DOI: 10.1007/s11240-022-02333-1
• De Padua RM., Kratz JM., Munkert J., Bertol JW., Rigotto C., Schuster D., Maltarollo VG., Kreis W., Oliveira Simoes CM., Braga FC.:
  Effects of Lipophilicity and Structural Features on the Antiherpes Activity of Digitalis Cardenolides and Derivatives
  In: Chemistry & Biodiversity (2022)
  ISSN: 1612-1872
  DOI: 10.1002/cbdv.202200411
• Klein J., Ernst M., Christmann A., Tropper M., Leykauf T., Kreis W., Munkert J.:
  Knockout of arabidopsis thaliana vep1, encoding a prise (Progesterone 5β-reductase/iridoid synthase-like enzyme), leads to metabolic changes in response to exogenous methyl vinyl ketone (mvk)
  In: Metabolites 12 (2022), Art.Nr.: 11
  ISSN: 2218-1989
  DOI: 10.3390/metabo12010011

2021

• Dorfner M., Klein J., Lanig H., Kreis W., Munkert J.:
  Identifying structural features for changing substrate preferences in two Plantago PRISEs (pro-gesterone 5 beta-reductase and / or iridoid synthase)
  In: PLANTA MEDICA, STUTTGART: 2021
  DOI: 10.1055/s-0041-1736952
• Ignatova A., Klein J., Leykauf T., Kreis W., Munkert J.:
  Restoring cardenolide accumulation in RNAi-mediated DlP5 beta R1 and DlP5 beta R2 knockdown shoot culture lines of Digitalis lanata and studying the effects of precursor feeding on cardenolide free dark-cultured D. lanata shoots
  In: PLANTA MEDICA, STUTTGART: 2021
  DOI: 10.1055/s-0041-1736902
• Klein J., Horn E., Ernst M., Leykauf T., Leupold T., Dorfner M., Wolf LS., Ignatova A., Kreis W., Munkert J.:
  RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content
  In: Plant Cell Reports (2021)
  ISSN: 0721-7714
  DOI: 10.1007/s00299-021-02707-3
• Leykauf T., Klein J., Lodel M., Kreis W., Munkert J.:
  Overexpression of 3 beta-hydroxysteroid dehydrogenases in Digitalis lanata shoot cultures
  In: PLANTA MEDICA, STUTTGART: 2021
  DOI: 10.1055/s-0041-1736957
• Tropper M., Höhn S., Wolf LS., Fritsch J., Kastner-Detter N., Rieck C., Munkert J., Meitinger N., Lanig H., Kreis W.:
  21-Hydroxypregnane 21-O-malonylation, a crucial step in cardenolide biosynthesis, can be achieved by substrate-promiscuous BAHD-type phenolic glucoside malonyltransferases from Arabidopsis thaliana and homolog proteins from Digitalis lanata
  In: Phytochemistry 187 (2021), Art.Nr.: 112710
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2021.112710
• Tropper M., Wolf LS., Lanig H., Kreis W.:
  In silico, in vitro, and structural investigations on BAHD-enzymes from different species able to malonylate 21-hydroxypregnanes
  In: PLANTA MEDICA, STUTTGART: 2021
  DOI: 10.1055/s-0041-1736873
• Zanchett Schneider NF., Menegaz D., Andreotti Dagostin AL., Persich L., Rocha SC., Pacheco Ramos AC., Cortes VF., Leite Fontes CF., De Padua RM., Munkert J., Kreis W., Braga FC., Barbosa LA., Mena Barreto Silva FR., Oliveira Simoes CM.:
  Cytotoxicity of glucoevatromonoside alone and in combination with chemotherapy drugs and their effects on Na+,K+-ATPase and ion channels on lung cancer cells
  In: Molecular and Cellular Biochemistry (2021)
  ISSN: 0300-8177
  DOI: 10.1007/s11010-020-04040-x

2020

• Boff L., Persich L., Brambila P., Ottoni FM., Munkert J., Ramos GS., Soares Viana AR., Kreis W., Braga FC., Alves RJ., Maia de Pádua R., Schneider NFZ., Simões CMO.:
  Investigation of the cytotoxic activity of two novel digitoxigenin analogues on H460 lung cancer cells
  In: Anti-Cancer Drugs 31 (2020), S. 452-462
  ISSN: 0959-4973
  DOI: 10.1097/CAD.0000000000000872
• Boff L., Schneider NFZ., Munkert J., Ottoni FM., Ramos GS., Kreis W., Braga FC., Alves RJ., Maia de Pádua R., Simões CMO.:
  Elucidation of the mechanism of anti-herpes action of two novel semisynthetic cardenolide derivatives.
  In: Archives of Virology (2020), S. 1385-1396
  ISSN: 0304-8608
  DOI: 10.1007/s00705-020-04562-1
• Boff L., Schreiber A., Matos AdR., Del Sarto JL., Brunotte L., Munkert J., Ottoni FM., Ramos GS., Kreis W., Braga FC., Alves RJ., Maia de Pádua R., Simões CMO., Ludwig S.:
  Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation
  In: Molecules (2020)
  ISSN: 1420-3049
  DOI: 10.3390/molecules25204853
• Horn E., Kemmler Y., Kreis W., Munkert J.:
  Cardenolide and glucosinolate accumulation in shoot cultures of Erysimum crepidifolium Rchb.
  In: In Vitro Cellular & Developmental Biology-Plant (2020)
  ISSN: 1054-5476
  DOI: 10.1007/s11627-020-10135-3
• Scheer R., Alban S., Becker H., Beer AM., Blaschek W., Klein R., Kreis W., Leneweit G., Matthes H., Spahn G., Stange R. (Hrsg.):
  Die Mistel in der Tumortherapie 5, aktueller Stand der Forschung und klinische Anwendung
  Essen: 2020
  ISBN: 978-3-96562-030-8

2019

• Boff L., Munkert J., Ottoni FM., Schneider NFZ., Ramos GS., Kreis W., Andrade SF., De Souza Filho JD., Braga FC., Alves RJ., De Padua RM., Simões CMO.:
  Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives
  In: European Journal of Medicinal Chemistry 167 (2019), S. 546-561
  ISSN: 0223-5234
  DOI: 10.1016/j.ejmech.2019.01.076
• Boff L., Munkert J., Ottoni FM., Zanchett Schneider NF., Ramos GS., Kreis W., De Andrade SF., Dias De Souza Filho J., Castro Braga F., Alves RJ., Maia De Padua R., Simões CMO.:
  Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives
  67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck, 1. September 2019 - 5. September 2019)
  In: PLANTA MEDICA, STUTTGART: 2019
  DOI: 10.1055/s-0039-3399709
• Kreis W.:
  Exploiting plant cell culture for natural product formation
  In: Journal of Applied Botany and Food Quality-Angewandte Botanik 92 (2019), S. 216-225
  ISSN: 1613-9216
  DOI: 10.5073/JABFQ.2019.092.030
• Kreis W., Munkert J.:
  Exploiting enzyme promiscuity to shape plant specialized metabolism
  In: Journal of Experimental Botany 70 (2019), S. 1435-1445
  ISSN: 0022-0957
  DOI: 10.1093/jxb/erz025
• Leykauf T., Klein J., Ernst M., Kreis W., Munkert J.:
  RNAi mediated knock down of 3 beta-hydroxysteroid dehydrogenases in Digitalis lanata shoot cultures
  67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck, 1. September 2019 - 5. September 2019)
  In: PLANTA MEDICA, STUTTGART: 2019
  DOI: 10.1055/s-0039-3399800
• Rieck C., Geiger D., Munkert J., Messerschmidt K., Petersen J., Strasser J., Meitinger N., Kreis W.:
  Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae
  In: MicrobiologyOpen (2019), Art.Nr.: e925
  ISSN: 2045-8827
  DOI: 10.1002/mbo3.925
• Tropper M., Höhn S., Munkert J., Kreis W.:
  BAHD-like malonyltransferase genes from Digitalis lanata and Arabidopsis thaliana and their putative role in cardenolide biosynthesis
  67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) (Innsbruck, 1. September 2019 - 5. September 2019)
  In: PLANTA MEDICA, STUTTGART: 2019
  DOI: 10.1055/s-0039-3399788

2018

• Meitinger N., Kreis W.:
  Development and validation of a quick assay for the total glucosinolate content in horseradish (Armoracia rusticana) using glucose strips and a blood glucose meter
  In: Journal of Applied Botany and Food Quality-Angewandte Botanik 91 (2018), S. 232-236
  ISSN: 1613-9216
  DOI: 10.5073/JABFQ.2018.091.031
• Schmidt K., Petersen J., Munkert J., Egerer-Sieber C., Hornig M., Muller Y., Kreis W.:
  PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism.
  In: Phytochemistry 156 (2018), S. 9-19
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2018.08.012
• Schneider NFZ., Cerella C., Lee JY., Mazumder A., Kim KR., de Carvalho A., Munkert J., De Padua RM., Kreis W., Kim KW., Christov C., Dicato M., Kim HJ., Han BW., Braga FC., Simões CMO., Diederich M.:
  Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-specific Cell Death
  In: Frontiers in Pharmacology 9 (2018), Art.Nr.: 70
  ISSN: 1663-9812
  DOI: 10.3389/fphar.2018.00070
• Silva IT., Munkert J., Nolte E., Schneider NFZ., Rocha SC., Ramos ACP., Kreis W., Braga FC., De Padua RM., Taranto AG., Cortes VF., Barbosa LA., Wach S., Taubert H., Simões CMO.:
  Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+ -ATPase inhibition.
  In: Biomedicine & Pharmacotherapy 107 (2018), S. 464-474
  ISSN: 0753-3322
  DOI: 10.1016/j.biopha.2018.08.028
• Yücesan B., Eker İ., Lazzarini LES., Aslam N., Mohammed A., Pinto JEBP., Kreis W., Gürel E.:
  Shoot-tip Cultivation and Cardenolide Content Analysis of Natural Populations of Digitalis lanata Ehrh. subsp. lanata (wooly foxglove) in Thrace Region
  In: International Journal of Agriculture and Wildlife Science 4 (2018), S. 55-62
  ISSN: 2149-8245
  DOI: 10.24180/ijaws.390582

2017

• Kreis W.:
  The Foxgloves (Digitalis) Revisited
  In: Planta Medica (2017)
  ISSN: 0032-0943
  DOI: 10.1055/s-0043-111240
• Kreis W., Munkert J., De Padua RM.:
  Biossíntese de metabólitos primários e secundários
  In: Letícia Bispo de Lima (Hrsg.): Farmacognosia do Produto Natural ao Medicamento, Porto Alegre, Brazil: Artmed Editora Ltda., 2017, S. 147 - 166
  ISBN: 978-85-8271-359-4
• Munkert J., Kreis W.:
  Herzglykoside und ihr Potenzial für die Tumortherapie
  In: Deutsche Zeitschrift für Onkologie 49 (2017), S. 129-135
  ISSN: 0931-0037
  DOI: 10.1055/s-0043-115681
• Munkert J., Santiago Franco M., Nolte E., Silva IT., Oliveira Castilho R., Ottoni FM., Schneider NFZ., Oliveira MC., Taubert H., Bauer W., Andrade SF., Alves RJ., Simões CMO., Braga FC., Kreis W., De Padua RM.:
  Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture.
  In: Planta medica (2017)
  ISSN: 1439-0221
  DOI: 10.1055/s-0043-109557
• Nolte E., Wach S., Silva IT., Lukat S., Ekici AB., Munkert J., Müller-Uri F., Kreis W., Simões CMO., Vera González J., Wullich B., Taubert H., Lai X.:
  A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines
  In: Oncotarget 8 (2017), S. 11676-11691
  ISSN: 1949-2553
  DOI: 10.18632/oncotarget.14644
• Schneider NFZ., Persich L., Rocha SC., Ramos ACP., Cortes VF., Silva IT., Munkert J., De Padua RM., Kreis W., Taranto AG., Barbosa LA., Braga FC., Simões CMO.:
  Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase
  In: Biomedicine & Pharmacotherapy 97 (2017), S. 684-696
  ISSN: 0753-3322
  DOI: 10.1016/j.biopha.2017.10.128
• Schneider NFZ., Silva IT., Persich L., de Carvalho A., Rocha SC., Marostica LL., Ramos ACP., Taranto AG., De Padua RM., Kreis W., Barbosa LA., Braga FC., Simões CMO.:
  Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation
  In: Molecular and Cellular Biochemistry 428 (2017), S. 23-39
  ISSN: 0300-8177
  DOI: 10.1007/s11010-016-2914-8

2016

• Dingermann T., Kreis W., Nieber K., Rimpler H., Zündorf I.:
  Reinhard Pharmazeutische Biologie, Grundlagen und Humanbiologie
  Stuttgart: Wissenschaftliche Verlagsgesellschaft, 2016
  ISBN: 978-3-8047-3261-2
• Eker İ., Yücesan B., Sameeullah M., Welß W., Müller-Uri F., Gürel E., Kreis W.:
  Phylogeny of Anatolian (Turkey) species in the Digitalis sect. Globiflorae (Plantaginaceae)
  In: Phytotaxa 244 (2016), S. 263-282
  ISSN: 1179-3155
  DOI: 10.11646/phytotaxa.244.3.3
• Kreis W.:
  Lektine: Potentielle Quellen und Anwendungen
  In: Scheer Rainer, Alban Susanne, Becker Hans, Beer André-Michael, Blaschek Wolfgang, Kreis Wolfgang, Matthes Harald, Schilcher Heinz, Spahn Günther, Stange Rainer (Hrsg.): Die Mistel in der Tumortherapie 4. Aktueller Stand der Forschung und klinische Anwendung, Essen: KVC Verlag, 2016
  ISBN: 978-3-945150-68-9
• Maia de Pádua R., Meitinger N., Hennemann M., Schebitz P., Waibel R., Löber S., Gmeiner P., Clark T., Kreis W.:
  Spontaneous butenolide ring formation of pregnane-21-O-malonyl hemiesters under mild reaction conditions is facilitated by the 14β-hydroxy group present in all natural cardenolides
  In: Tetrahedron 72 (2016), S. 4556-4563
  ISSN: 0040-4020
  DOI: 10.1016/j.tet.2016.06.024
• Meitinger N., Munkert J., Maia de Pádua R., De Souza Filho JD., Maid H., Bauer W., Braga FC., Kreis W.:
  The catalytic mechanism of the 3-ketosteroid isomerase of Digitalis lanata involves an intramolecular proton transfer and the activity is not associated with the 3 beta-hydroxysteroid dehydrogenase activity
  In: Tetrahedron Letters 57 (2016), S. 1567-1571
  ISSN: 0040-4039
  DOI: 10.1016/j.tetlet.2016.02.099
• Rudolph K., Parthier C., Egerer-Sieber C., Geiger D., Muller Y., Kreis W., Müller-Uri F.:
  Expression, crystallization and structure elucidation of γ-terpinene synthase from Thymus vulgaris
  In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications 72 (2016), S. 16-23
  ISSN: 1744-3091
  DOI: 10.1107/S2053230X15023043
• Sahin S., Eulenburg V., Kreis W., Villmann C., Pischetsrieder M.:
  Three-step test system for the identification of novel GABAa receptor modulating food plants
  In: Plant Foods For Human Nutrition 71 (2016), S. 355-360
  ISSN: 0921-9668
  DOI: 10.1007/s11130-016-0566-1
  URL: http://rdcu.be/nkD9
• Yücesan B., Mohammed A., Eker İ., Sameeullah M., Demir-Ordu Ö., Cihangir C., Şahbaz N., Kaya Ö., Müller-Uri F., Kreis W., Gürel E.:
  In vitro propagation and cardenolide profiling of Digitalis ferruginea subsp schischkinii, a medicinally important foxglove species with limited distribution in Northern Turkey
  In: In Vitro Cellular & Developmental Biology-Plant 52 (2016), S. 322-329
  ISSN: 1054-5476
  DOI: 10.1007/s11627-016-9759-4
• Yücesan B., Mohammed A., Eker İ., Sameeullah M., Demir-Ordu Ö., Cihangir C., Şahbaz N., Kaya Ö., Müller-Uri F., Kreis W., Gürel E.:
  In vitro propagation and cardenolide profiling of Digitalis ferruginea subsp. schischkinii, a medicinally important foxglove species with limited distribution in Northern Turkey
  In: In Vitro Cellular & Developmental Biology-Plant (2016)
  ISSN: 1054-5476

2015

• Mohammed A., Yücesan B., Demir-Ordu Ö., Cihangir C., Eker İ., Kreis W., Gürel E.:
  In vitro regeneration and cardenolide determination of an endemic foxglove, Digitalis cariensis (Aegean Foxglove)
  In: In Vitro Cellular & Developmental Biology-Plant 51 (2015), S. 438-444
  ISSN: 1054-5476
  DOI: 10.1007/s11627-015-9697-6
• Munkert J., Costa C., Budeanu O., Petersen J., Bertolucci S., Fischer G., Müller-Uri F., Kreis W.:
  Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers
  In: Plant Biology 17 (2015), S. 1113-1122
  ISSN: 1435-8603
  DOI: 10.1111/plb.12361
• Munkert J., Pollier J., Miettinen K., Van Moerkercke A., Payne R., Müller-Uri F., Burlat V., O'Connor SE., Memelink J., Kreis W., Goossens A.:
  Iridoid Synthase Activity is Common among the Plant Progesterone 5β-Reductase Family
  In: Molecular Plant 8 (2015), S. 136-152
  ISSN: 1674-2052
  DOI: 10.1016/j.molp.2014.11.005
• Nolte E., Sobel A., Wach S., Hertlein H., Ebert N., Müller-Uri F., Slany R., Taubert H., Wullich B., Kreis W.:
  The new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) efficiently suppresses cell growth in human leukemia and urologic tumor cell lines
  In: Anticancer Research 35 (2015), S. 5271-5276
  ISSN: 0250-7005
  URL: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942815459&origin=inward
• Petersen J., Lanig H., Munkert J., Bauer P., Müller-Uri F., Kreis W.:
  Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations
  In: Journal of Biomolecular Structure & Dynamics (2015), S. 1-14
  ISSN: 0739-1102
  DOI: 10.1080/07391102.2015.1088797
• Schneider NFZ., Geller FC., Persich L., Marostica LL., Maia de Pádua R., Kreis W., Braga FC., Simões CMO.:
  Inhibition of cell proliferation, invasion and migration by the cardenolides digitoxigenin monodigitoxoside and convallatoxin in human lung cancer cell line
  In: Natural Product Research (2015), S. 1-5
  ISSN: 1478-6419
  DOI: 10.1080/14786419.2015.1055265

2014

• Kreis W., Haug B., Yücesan B.:
  Somaclonal variation of cardenolide content in Heywood's foxglove, a source for the antiviral cardenolide glucoevatromonoside, regenerated from permanent shoot culture and callus
  In: In Vitro Cellular & Developmental Biology-Plant 51 (2014), S. 35-41
  ISSN: 1054-5476
  DOI: 10.1007/s11627-014-9642-0
• Loebers A., Müller-Uri F., Kreis W.:
  A young root-specific gene (ArMY2) from horseradish encoding a MYR II myrosinase with kinetic perference for the root-specific glucosinolate gluconasturtiin
  In: Phytochemistry 99 (2014), S. 26-35
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2013.11.008
• Meitinger N., Geiger D., Augusto TW., Maia de Pádua R., Kreis W.:
  Purification of Δ(5)-3-ketosteroid isomerase from Digitalis lanata
  In: Phytochemistry 109 (2014), S. 6-13
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2014.10.025
• Munkert J., Ernst M., Müller-Uri F., Kreis W.:
  Identification and stress-induced expression of three 3β-hydroxysteroid dehydrogenases from Erysimum crepidifolium Rchb. and their putative role in cardenolide biosynthesis
  In: Phytochemistry 100 (2014), S. 26-33
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2014.01.006
• Rudolph K., Bauer P., Schmid B., Müller-Uri F., Kreis W.:
  Truncation of N-terminal regions of Digitalis lanata progesterone 5β-reductase alters catalytic efficiency and substrate preference
  In: Biochimie 101 (2014), S. 31-38
  ISSN: 0300-9084
  DOI: 10.1016/j.biochi.2013.12.010

2013

• Kreis W., Müller-Uri F.:
  Cardenolide aglycone formation in Digitalis
  In: Bach Thomas J., Rohmer Michel (Hrsg.): Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches, New York: Springer Science + Business Media, 2013, S. 425-438
  ISBN: 978-1-4614-4062-8
  DOI: 10.1007/978-1-4614-4063-5_29
• Scheer R., Alban S., Becker H., Blaschek W., Kemper F., Kreis W., Matthes H., Schilcher H., Stange R. (Hrsg.):
  Die Mistel in der Tumortherapie 3. Aktueller Stand der Forschung und klinische Anwendung
  Essen: 2013
  ISBN: 978-3-86864-032-8
• Yücesan B., Müller-Uri F., Kreis W., Gürel E.:
  Cardenolide estimation in callus-mediated regenerants of Digitalis lamarckii Ivanina (dwarf foxglove)
  In: In Vitro Cellular & Developmental Biology-Plant 50 (2013), S. 137-142
  ISSN: 1054-5476
  DOI: 10.1007/s11627-013-9549-1

2012

• Bauer P., Rudolph K., Müller-Uri F., Kreis W.:
  Vein Patterning 1-encoded progesterone 5beta-reductase: Activity-guided improvement of catalytic efficiency
  In: Phytochemistry 77 (2012), S. 53-59
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2012.01.022
• Durchschein K., Wallner S., Macheroux P., Schwab W., Winkler T., Kreis W., Faber K.:
  Nicotinamide-Dependent Ene Reductases as Alternative Biocatalysts for the Reduction of Activated Alkenes
  In: European Journal of Organic Chemistry 2012 (2012), S. 4963-4968
  ISSN: 1434-193X
  DOI: 10.1002/ejoc.201200776
• Maia de Pádua R., Meitinger N., de Souza Filho JD., Waibel R., Gmeiner P., Braga FC., Kreis W.:
  Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W.1.4)
  In: Steroids 77 (2012), S. 1373-1380
  ISSN: 0039-128X
  DOI: 10.1016/j.steroids.2012.07.016

2011

• Bauer P., Kreis W.:
  Curcumin in der Krebstherapie
  In: Deutsche Zeitschrift für Onkologie 41 (2011), S. 144-149
  ISSN: 0931-0037
  DOI: 10.1055/s-0030-1257694
• Bauer P., Müller-Uri F., Kreis W., Burda E., Munkert J.:
  Progesterone 5β-reductase of Erysimum crepidifolium: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant protein
  In: Phytochemistry 72 (2011), S. 1710-1717
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2011.06.007
• Bertol JW., Rigotto C., Maia de Pádua R., Kreis W., Barardi CRM., Braga FC., Simões CMO.:
  Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata.
  In: Antiviral Research 92 (2011), S. 73-90
  ISSN: 0166-3542
  DOI: 10.1016/j.antiviral.2011.06.015
• Clemente ES., Müller-Uri F., Nebauer SG., Segura J., Kreis W., Arrillaga I.:
  Digitalis
  In: Kole Chittaranjan (Hrsg.): Wild Crop Relatives: Genomic and Breeding Resources, Plantaton and Ornamental Crops, Berlin Heidelberg: Springer, 2011, S. 73-112
  ISBN: 978-3-642-21201-7
  DOI: 10.1007/978-3-642-21200-0

2010

• Bauer P., Munkert J., Brydziun M., Burda E., Müller-Uri F., Gröger H., Muller Y., Kreis W.:
  Highly conserved progesterone 5β-reductase (P5βR) genes, from 5β-cardenolide-free and 5β-cardenolide-producing angiosperms.
  In: Phytochemistry 71 (2010), S. 1495-1505
  ISSN: 0031-9422
  DOI: 10.1016/j.phytochem.2010.06.004
• Baumgertel A., Loebers A., Kreis W.:
  Buckwheat is a Source for the Herbal Drug Fagopyri herba: Rutin Content and Activity of Flavonoid-Degrading Enzymes during Plant Development.
  In: The European Journal of Plant Science and Biotechnology Special Issue 1 (2010), S. 82-86
  ISSN: 1752-3842
• Kreis W.:
  Enzyme bei der Gewinnung von Drogen und der Herstellung von Phytopharmaka.
  In: Hänsel Rudolf, Sticher Otto (Hrsg.): Pharmakognosie - Phytopharmazie, Berlin Heidelberg NY: Springer, 2010, S. 273-279
  ISBN: 978-3-642-00962-4
• Kreis W.:
  Prinzipien des Sekundärstoffwechsels
  In: Hänsel Rudolf, Sticher Otto (Hrsg.): Pharmakognosie - Phytopharmazie, Belin, Heidelberg, New York: Springer, 2010, S. 3-27
  ISBN: 978-3-642-00962-4
• Kreis W., Müller-Uri F.:
  Biochemistry of sterols, cardiac glycosides, brassinosteroids, phytoecdysteroids and steroid saponins
  In: Wink M (Hrsg.): Biochemistry of Plant Secondary Metabolism. Annual Review Plant, Sheffield: CRC Press, 2010, S. 304-363
  ISBN: 9781405183970
  DOI: 10.1002/9781444320503.ch6
• Müller-Uri F., Kreis W.:
  Recent Advances in Cardenolide Research.
  In: Journal of Academy of Sciences of Moldova (Hrsg.): Buletinul Academiei de Stiinte a Moldovei, Chisinau: , 2010, S. 45-52